miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells

miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells

Abstract TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively reg...

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Veröffentlicht in:Cancer letters 2014-05, Vol.347 (1), p.98-104
Hauptverfasser: Liu, Jingjing, Wang, Xu, Yang, Xiaoning, Liu, Yunpeng, Shi, Ying, Ren, Jianlin, Guleng, Bayasi
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Base Sequence
beta Catenin - metabolism
Cell growth
Cell Line, Tumor
Cell Proliferation
Cyclin D - metabolism
DNA Primers
Expression regulation
Gastric cancer
Gene expression
Hematology, Oncology and Palliative Medicine
Humans
MicroRNAs
MicroRNAs - physiology
miR-423-5p
Neoplasm Invasiveness
Phase transitions
Polymerase Chain Reaction
Proliferation and invasion
Proteins
Rodents
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Trefoil factor 1 (TFF1)
Trefoil Factor-1
Tumor Suppressor Proteins - physiology
Tumors
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Zusammenfassung:Abstract TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3′UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.01.024