Redox proteomics and the dynamic molecular landscape of the aging brain

Highlights • Aging is the major risk factor for development of many neurodegenerative diseases. • Protein oxidation increases in the brain with age. • Oxidative modifications of proteins impair their function. • Elevation of oxidized/misfolded brain proteins occurs in aging and neurodegeneration. •...

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Veröffentlicht in:	Ageing research reviews 2014, Vol.13, p.75-89
Hauptverfasser:	Perluigi, Marzia, Swomley, Aaron M, Butterfield, D. Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging - metabolism Aging - pathology Animals Biological and medical sciences Biomarkers - metabolism Brain - metabolism Brain - pathology Caloric Restriction Development. Metamorphosis. Moult. Ageing Dogs Environment. Living conditions Fundamental and applied biological sciences. Psychology General aspects Humans Internal Medicine Medical sciences Mice Models, Animal Nerve Degeneration Nerve Tissue Proteins - metabolism Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurology Oxidation-Reduction Protein Processing, Post-Translational Proteomics - methods Public health. Hygiene Public health. Hygiene-occupational medicine Rats Time Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Beschreibung
Zusammenfassung:	Highlights • Aging is the major risk factor for development of many neurodegenerative diseases. • Protein oxidation increases in the brain with age. • Oxidative modifications of proteins impair their function. • Elevation of oxidized/misfolded brain proteins occurs in aging and neurodegeneration. • Proteomics has provided insights into the role of protein oxidation in brain aging.
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2013.12.005