Role of SIRT1 and AMPK in mesenchymal stem cells differentiation

Highlights • SIRT1 and AMPK might mediate calorie restriction effect on MSCs differentiation. • SIRT1 favors MSCs differentiation toward osteoblast instead of adipocyte lineage. • AMPK favors MSCs differentiation toward osteoblast instead of adipocyte lineage. • Mechanisms of SIRT1 and AMPK action o...

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Veröffentlicht in:	Ageing research reviews 2014-01, Vol.13, p.55-64
Hauptverfasser:	Chen, Huiqiang, Liu, Xianbao, Chen, Han, Cao, Jiang, Zhang, Ling, Hu, Xinyang, Wang, Jiańan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - enzymology Adipogenesis AMP-Activated Protein Kinases - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Caloric Restriction Cell Differentiation - drug effects Cell Lineage Development. Metamorphosis. Moult. Ageing Energy Metabolism Enzyme Activation Enzyme Activators - pharmacology Fundamental and applied biological sciences. Psychology General aspects Humans Internal Medicine Medical sciences Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - enzymology Neurology Osteoblasts - enzymology Osteogenesis Signal Transduction Sirtuin 1 - metabolism Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	Highlights • SIRT1 and AMPK might mediate calorie restriction effect on MSCs differentiation. • SIRT1 favors MSCs differentiation toward osteoblast instead of adipocyte lineage. • AMPK favors MSCs differentiation toward osteoblast instead of adipocyte lineage. • Mechanisms of SIRT1 and AMPK action on MSCs differentiation were reviewed. • Synergistic interaction of SIRT1 and AMPK in MSCs differentiation was discussed.
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2013.12.002