Long-term carcinogenicity bioassay on vinylidene chloride administered by inhalation to Sprague-Dawley rats. New results

Vinylidene chloride was administered by inhalation, 7 hours daily, 5 days weekly, at the concentration of 100 and 0 ppm, to Sprague-Dawley rats. The treatment was started on 13-week-old breeders, and male and female offspring (12-day embryos). The breeders and some of the offspring were exposed for...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1988, Vol.534, p.160
Hauptverfasser:	Cotti, G, Maltoni, C, Lefemine, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Biological Assay Dichloroethylenes - administration & dosage Dichloroethylenes - toxicity Female Hydrocarbons, Chlorinated - toxicity Male Molecular Weight Mutagenicity Tests Rats Rats, Inbred Strains Time Factors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Vinylidene chloride was administered by inhalation, 7 hours daily, 5 days weekly, at the concentration of 100 and 0 ppm, to Sprague-Dawley rats. The treatment was started on 13-week-old breeders, and male and female offspring (12-day embryos). The breeders and some of the offspring were exposed for 104 weeks; the other offspring were exposed for 15 weeks only. An increased incidence was found of malignant tumors and of leukemias, particularly in offspring treated for 104 weeks.
ISSN:	0077-8923
DOI:	10.1111/j.1749-6632.1988.tb30109.x