Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice

To investigate whether Jieduxiezhuo decoction (JDXZD) can prevent serum uric acid elevations in mice. Hyperuricemia in mice was induced by intraperitoneally administering uric acid (250 mg/ kg). Concentrations of uric acid in serum were determined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered. After intraperitoneal injection of uric acid, serum uric acid concentrations in mice significantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups. Pretreatment with JDXZD slowed increases in serum uric acid levels in mice intraperitoneally administered uric acid.