Occurrence of the mycotoxin cyclopiazonic acid in meat after oral administration to chickens

Four-week old chickens were administered 0.5, 5.0, or 10.0 mg of cyclopiazonic acid (CPA)/kg of body weight by crop intubation and were killed 3, 24, 48, or 96 h later. Breast and thigh muscle was removed from the carcasses, and the content of CPA in the meat was measured by a high-performance liquid chromatographic procedure. CPA was found in the meat from birds in each dose group, and the amount found was dependent on both dose given and the elapsed time after dosing. The maximum muscle content of CPA occurred 3 h after administration and ranged from 50 ppb in birds given 0.5 mg/kg to over 5000 ppb in some birds given 10.0 mg/kg. Birds given the highest dose of CPA eliminated CPA from meat at a slower rate than other treatment groups.