Palladium-Catalyzed Direct Arylation of Indoles with Cyclohexanones

A novel palladium catalyzed approach to 3-arylindoles was developed from indoles and cyclohexanones. Various cyclohexanones acted as aryl sources via an alkylation and dehydrogenation sequence using molecular oxygen as the hydrogen acceptor. This method showed good regioselectivity and afforded 3-ar...

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Veröffentlicht in:	Organic letters 2014-03, Vol.16 (6), p.1618-1621
Hauptverfasser:	Chen, Shanping, Liao, Yunfeng, Zhao, Feng, Qi, Hongrui, Liu, Saiwen, Deng, Guo-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Combinatorial Chemistry Techniques Cyclohexanones - chemistry Heterocyclic Compounds, 3-Ring - chemical synthesis Heterocyclic Compounds, 3-Ring - chemistry Indoles - chemical synthesis Indoles - chemistry Molecular Structure Palladium - chemistry
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Beschreibung
Zusammenfassung:	A novel palladium catalyzed approach to 3-arylindoles was developed from indoles and cyclohexanones. Various cyclohexanones acted as aryl sources via an alkylation and dehydrogenation sequence using molecular oxygen as the hydrogen acceptor. This method showed good regioselectivity and afforded 3-arylindoles as the sole products.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol500231c