SEMG1 may be the candidate gene for idiopathic asthenozoospermia

Summary Asthenozoospermia (AZS) is a major cause of male infertility, aetiology of which is reported to be related with gene mutation or deletion. However, studies on candidate genes for AZS are very scarce. In this study, we examined the gene expression profiles of asthenozoosperm. Gene expression profile analyses with microarray on spermatozoa specimens from 12 asthenozoosperm patients and 12 age‐matched volunteers were performed; data analysis was performed with bioinformatics tools. Data analysis revealed that 1265 and 262 genes were significantly (P