NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric proces...

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Veröffentlicht in:	Organic & biomolecular chemistry 2014-04, Vol.12 (15), p.2388-2393
Hauptverfasser:	Youn, So Won, Song, Hyoung Sub, Park, Jong Hyub
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzofurans - chemical synthesis Benzofurans - chemistry Catalysis Cyclization Heterocyclic Compounds - chemistry Methane - analogs & derivatives Methane - chemistry Oxidation-Reduction
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Beschreibung
Zusammenfassung:	An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c3ob42546k