Normal values for high‐resolution anorectal manometry/topography in a healthy Korean population and the effects of gender and body mass index

Background High‐resolution manometry (HRM) based on spatiotemporal plots is increasingly being used. The aim this study was to evaluate, for the first time, the influence of gender, with adjustment for age, body mass index (BMI), and vaginal delivery, on anorectal functions in asymptomatic adults. Methods Fifty‐four asymptomatic healthy subjects (M : F = 27 : 27; age = 20–67 years) who were matched by age and gender were enrolled prospectively. We evaluated anorectal pressures, rectal sensation using a HRM probe, and balloon expulsion time. Multivariate linear regression analysis was performed to identify the independent effects of each factor. Key Results Anal resting pressure (median [IQR]; 32 [18] vs 46 [17] mmHg, p