A Selective Artificial Enzyme Inhibitor Based on Nanoparticle-Enzyme Interactions and Molecular Imprinting

A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and...

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Veröffentlicht in:	Advanced materials (Weinheim) 2013-11, Vol.25 (41), p.5922-5927
Hauptverfasser:	Zheng, Cheng, Zhang, Xiao-Long, Liu, Wei, Liu, Bo, Yang, Huang-Hao, Lin, Zi-An, Chen, Guo-Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Chymotrypsin - antagonists & inhibitors Drug Design enzyme inhibitor Enzymes Models, Molecular Molecular Conformation molecular imprinted polymers Molecular Imprinting molecular recognition nanoparticles Nanoparticles - chemistry Nanotubes, Carbon - chemistry Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology
Online-Zugang:	Volltext
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