A Selective Artificial Enzyme Inhibitor Based on Nanoparticle-Enzyme Interactions and Molecular Imprinting

A Selective Artificial Enzyme Inhibitor Based on Nanoparticle-Enzyme Interactions and Molecular Imprinting

A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and...

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Veröffentlicht in:Advanced materials (Weinheim) 2013-11, Vol.25 (41), p.5922-5927
Hauptverfasser: Zheng, Cheng, Zhang, Xiao-Long, Liu, Wei, Liu, Bo, Yang, Huang-Hao, Lin, Zi-An, Chen, Guo-Nan
Format: Artikel
Sprache:eng
Schlagworte:
Chymotrypsin - antagonists & inhibitors
Drug Design
enzyme inhibitor
Enzymes
Models, Molecular
Molecular Conformation
molecular imprinted polymers
Molecular Imprinting
molecular recognition
nanoparticles
Nanoparticles - chemistry
Nanotubes, Carbon - chemistry
Polymers - chemical synthesis
Polymers - chemistry
Polymers - pharmacology
Protease Inhibitors - chemical synthesis
Protease Inhibitors - chemistry
Protease Inhibitors - pharmacology
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Zusammenfassung:A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and shows great target‐selectivity over other enzymes of similar function and proteins of compaable mole cular weight.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201302064