A Selective Artificial Enzyme Inhibitor Based on Nanoparticle-Enzyme Interactions and Molecular Imprinting
A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2013-11, Vol.25 (41), p.5922-5927 |
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| container_end_page | 5927 |
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| container_issue | 41 |
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| container_title | Advanced materials (Weinheim) |
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| creator | Zheng, Cheng Zhang, Xiao-Long Liu, Wei Liu, Bo Yang, Huang-Hao Lin, Zi-An Chen, Guo-Nan |
| description | A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and shows great target‐selectivity over other enzymes of similar function and proteins of compaable mole cular weight. |
| doi_str_mv | 10.1002/adma.201302064 |
| format | Article |
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Mater</addtitle><description>A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and shows great target‐selectivity over other enzymes of similar function and proteins of compaable mole cular weight.</description><subject>Chymotrypsin - antagonists & inhibitors</subject><subject>Drug Design</subject><subject>enzyme inhibitor</subject><subject>Enzymes</subject><subject>Models, Molecular</subject><subject>Molecular Conformation</subject><subject>molecular imprinted polymers</subject><subject>Molecular Imprinting</subject><subject>molecular recognition</subject><subject>nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>Protease Inhibitors - chemical synthesis</subject><subject>Protease Inhibitors - chemistry</subject><subject>Protease Inhibitors - pharmacology</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0EoqGwZYm8ZDPB78dyKG2J1LRChbC0HM8dcJnxBHsChF_PRClRd13dzXc-6dyD0GtK5pQQ9s43vZ8zQjlhRIknaEYlo5UgVj5FM2K5rKwS5gS9KOWOEGIVUc_RCeNWSsvVDN3V-BY6CGP8BbjOY2xjiL7D5-nvrge8SN_jOo5Dxu99gQYPCV_7NGz8RIYOqiM2QvaTZEgF-9Tg5TA5t53PeNFvckxjTN9eomet7wq8ur-n6MvF-eezj9XVzeXirL6qgpBKVEqrtaGtYcBYkI0xYExgohFWy7W2RGovlAeuCEyUlUEISlkL0BhNpdT8FL09eDd5-LmFMro-lgBd5xMM2-KoJMYKQpV5HBVaSsm42KPzAxryUEqG1k29ep93jhK3n8Ltp3DHKabAm3v3dt1Dc8T__34C7AH4HTvYPaJz9Ydl_VBeHbKxjPDnmPX5h1Oaa-m-Xl-6lV1dkOXq1n3i_wB9E6Qb</recordid><startdate>20131106</startdate><enddate>20131106</enddate><creator>Zheng, Cheng</creator><creator>Zhang, Xiao-Long</creator><creator>Liu, Wei</creator><creator>Liu, Bo</creator><creator>Yang, Huang-Hao</creator><creator>Lin, Zi-An</creator><creator>Chen, Guo-Nan</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20131106</creationdate><title>A Selective Artificial Enzyme Inhibitor Based on Nanoparticle-Enzyme Interactions and Molecular Imprinting</title><author>Zheng, Cheng ; 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| ispartof | Advanced materials (Weinheim), 2013-11, Vol.25 (41), p.5922-5927 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Chymotrypsin - antagonists & inhibitors Drug Design enzyme inhibitor Enzymes Models, Molecular Molecular Conformation molecular imprinted polymers Molecular Imprinting molecular recognition nanoparticles Nanoparticles - chemistry Nanotubes, Carbon - chemistry Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology |
| title | A Selective Artificial Enzyme Inhibitor Based on Nanoparticle-Enzyme Interactions and Molecular Imprinting |
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