Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii
Highlights • We confirmed the immunogenicity of TgPF in mice after Toxoplasma gondii infection. • TgPF-OML administration increased the survival of mice after Toxoplasma gondii infection. • TgPF-OML administration reduced the parasite burden in mouse brains after infection. • Immunization with TgPF-...
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| Veröffentlicht in: | Vaccine 2014-04, Vol.32 (16), p.1781-1785 |
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| container_title | Vaccine |
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| creator | Tanaka, Sachi Kuroda, Yasuhiro Ihara, Fumiaki Nishimura, Maki Hiasa, Jun Kojima, Naoya Nishikawa, Yoshifumi |
| description | Highlights • We confirmed the immunogenicity of TgPF in mice after Toxoplasma gondii infection. • TgPF-OML administration increased the survival of mice after Toxoplasma gondii infection. • TgPF-OML administration reduced the parasite burden in mouse brains after infection. • Immunization with TgPF-OML induced TgPF-specific interferon-γ and IgG production. |
| doi_str_mv | 10.1016/j.vaccine.2014.01.095 |
| format | Article |
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| ispartof | Vaccine, 2014-04, Vol.32 (16), p.1781-1785 |
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| subjects | Allergy and Immunology Animals Antibodies, Protozoan - blood Applied microbiology Biological and medical sciences Brain - parasitology Female Fundamental and applied biological sciences. Psychology Immune response Immune system Immunity, Cellular Immunity, Humoral Immunization Immunodominant Epitopes - immunology Infections Interferon-gamma - immunology Liposomes - immunology Mannose - chemistry Medical research Mice Mice, Inbred C57BL Microbiology Oligomannose-coated liposome Parasites Profilin Profilins - immunology Protozoan Proteins - immunology Protozoan Vaccines - immunology Recombinant Proteins - immunology Spleen - cytology Spleen - immunology Studies Toxoplasma Toxoplasma gondii Toxoplasmosis Toxoplasmosis, Animal - prevention & control Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii |
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