Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii

Highlights • We confirmed the immunogenicity of TgPF in mice after Toxoplasma gondii infection. • TgPF-OML administration increased the survival of mice after Toxoplasma gondii infection. • TgPF-OML administration reduced the parasite burden in mouse brains after infection. • Immunization with TgPF-...

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Veröffentlicht in:	Vaccine 2014-04, Vol.32 (16), p.1781-1785
Hauptverfasser:	Tanaka, Sachi, Kuroda, Yasuhiro, Ihara, Fumiaki, Nishimura, Maki, Hiasa, Jun, Kojima, Naoya, Nishikawa, Yoshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Protozoan - blood Applied microbiology Biological and medical sciences Brain - parasitology Female Fundamental and applied biological sciences. Psychology Immune response Immune system Immunity, Cellular Immunity, Humoral Immunization Immunodominant Epitopes - immunology Infections Interferon-gamma - immunology Liposomes - immunology Mannose - chemistry Medical research Mice Mice, Inbred C57BL Microbiology Oligomannose-coated liposome Parasites Profilin Profilins - immunology Protozoan Proteins - immunology Protozoan Vaccines - immunology Recombinant Proteins - immunology Spleen - cytology Spleen - immunology Studies Toxoplasma Toxoplasma gondii Toxoplasmosis Toxoplasmosis, Animal - prevention & control Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • We confirmed the immunogenicity of TgPF in mice after Toxoplasma gondii infection. • TgPF-OML administration increased the survival of mice after Toxoplasma gondii infection. • TgPF-OML administration reduced the parasite burden in mouse brains after infection. • Immunization with TgPF-OML induced TgPF-specific interferon-γ and IgG production.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.01.095