Sumatriptan/naproxen sodium for the acute treatment of probable migraine without aura: A randomized study

Objective Probable migraine is a common, disabling migraine subtype fulfilling all but one of the diagnostic criteria for migraine. This study was conducted to evaluate the efficacy and tolerability of sumatriptan/naproxen sodium for the acute treatment of probable migraine without aura. Methods Pat...

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Veröffentlicht in:Cephalalgia 2014-04, Vol.34 (4), p.268-279
Hauptverfasser: Silberstein, Stephen, McDonald, Susan A, Goldstein, Jerome, Aurora, Sheena, Lener, Shelly E, White, Jonathan, Runken, Michael C, Saiers, Jane, Derosier, Frederick, Lipton, Richard B
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Sprache:eng
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Zusammenfassung:Objective Probable migraine is a common, disabling migraine subtype fulfilling all but one of the diagnostic criteria for migraine. This study was conducted to evaluate the efficacy and tolerability of sumatriptan/naproxen sodium for the acute treatment of probable migraine without aura. Methods Patients treated a headache of probable migraine without aura when pain was moderate or severe with sumatriptan/naproxen sodium (n = 222 intent-to-treat (ITT)) or placebo (n = 221 ITT/complete case analysisa) in this randomized, double-blind, parallel-group study. Results Sumatriptan/naproxen sodium was more effective than placebo with respect to the co-primary efficacy endpoints two-hour pain-free response (29% sumatriptan/naproxen sodium vs 11% placebo, p 
ISSN:0333-1024
1468-2982
DOI:10.1177/0333102413508242