Propranolol as a treatment option in Gorham-Stout syndrome: A case report

Summary Gorham–Stout syndrome is a very rare syndrome characterized by progressive angiomatosis and lymphangiomas involving multiple organs. We describe herein a girl with progressive Gorham–Stout syndrome since the age of 13 years. Her disease involved the mediastinum, pericardium, vertebrae, ribs, and skull and did not respond to interferon and bisphosphonates. Propranolol administration was initiated at the age of 18 years and was associated with improvement in pulmonary function tests and involution of the mediastinal and hilar hemangiomatous lesions. The possible beneficial effect of propranolol in Gorham–Stout syndrome should be further investigated. Pediatr Pulmonol. 2014; 49:417–419. © 2013 Wiley Periodicals, Inc.