Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options
Neonatal stroke, including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis, remains a serious problem in the neonate. This article reviews the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options. Conclusion Although our understanding of the unde...
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| Veröffentlicht in: | Acta Paediatrica 2014-04, Vol.103 (4), p.356-364 |
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| container_end_page | 364 |
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| container_issue | 4 |
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| container_title | Acta Paediatrica |
| container_volume | 103 |
| creator | van der Aa, NE Benders, MJNL Groenendaal, F de Vries, LS |
| description | Neonatal stroke, including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis, remains a serious problem in the neonate. This article reviews the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options.
Conclusion
Although our understanding of the underlying mechanisms and possible risk factors has improved, little progress has been made towards therapeutic options. Considering the high incidence of neurological sequelae, the need for therapeutic options is high and should be the focus of future research. |
| doi_str_mv | 10.1111/apa.12555 |
| format | Article |
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Conclusion
Although our understanding of the underlying mechanisms and possible risk factors has improved, little progress has been made towards therapeutic options. Considering the high incidence of neurological sequelae, the need for therapeutic options is high and should be the focus of future research.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.12555</identifier><identifier>PMID: 24428836</identifier><language>eng</language><publisher>Norway: Blackwell Publishing Ltd</publisher><subject>Cerebral sinovenous thrombosis ; Drug therapy ; Epidemiology ; Humans ; Infant, Newborn ; MRI ; Neonatal stroke ; Pathogenesis ; Stroke - diagnosis ; Stroke - epidemiology ; Stroke - etiology ; Stroke - therapy</subject><ispartof>Acta Paediatrica, 2014-04, Vol.103 (4), p.356-364</ispartof><rights>2014 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 Foundation Acta Pædiatrica</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4615-138a9db76820553945e06f0bd40b1812a6a2783fd93243f92a0921fd1528751c3</citedby><cites>FETCH-LOGICAL-c4615-138a9db76820553945e06f0bd40b1812a6a2783fd93243f92a0921fd1528751c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.12555$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.12555$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24428836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Aa, NE</creatorcontrib><creatorcontrib>Benders, MJNL</creatorcontrib><creatorcontrib>Groenendaal, F</creatorcontrib><creatorcontrib>de Vries, LS</creatorcontrib><title>Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Neonatal stroke, including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis, remains a serious problem in the neonate. This article reviews the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options.
Conclusion
Although our understanding of the underlying mechanisms and possible risk factors has improved, little progress has been made towards therapeutic options. Considering the high incidence of neurological sequelae, the need for therapeutic options is high and should be the focus of future research.</description><subject>Cerebral sinovenous thrombosis</subject><subject>Drug therapy</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>MRI</subject><subject>Neonatal stroke</subject><subject>Pathogenesis</subject><subject>Stroke - diagnosis</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Stroke - therapy</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq2Kqiy0h_4BZIkLSAT8ETtObwvioxKCorbq0fImk8WQtVPbAfbf19sFDkj4MtbomUejeRH6Sskhze_IDOaQMiHEBzShUtCCMVZtoAlRhBeCCb6JtmK8I4TxupSf0CYrS6YUlxOUrsA7k0yPYwr-Hr5hgwM8WHjEvsPpFnAzhgAu4dxswTWAvcMw5P_C-t7Plwd4MOnWz8FBtPEAt9bMnY_JNhEb164cwQww5gb2Q7Lexc_oY2f6CF-e6zb6fXb66-SiuLw-_34yvSyaUlJRUK5M3c4qqRgRIq8ugMiOzNqSzKiizEjDKsW7tuas5F3NDKkZ7VoqmKoEbfg22lt7h-D_jhCTXtjYQN8bB36MmgqiSipqxTO6-wa982NwebsVJSuV70oytb-mmuBjDNDpIdiFCUtNiV5FoXMU-n8Umd15No6zBbSv5MvtM3C0Bh5tD8v3TXr6Y_qiLNYTNiZ4ep0w4V7LildC_7k61-XNBf15U0t9zP8B3Xeg7Q</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>van der Aa, NE</creator><creator>Benders, MJNL</creator><creator>Groenendaal, F</creator><creator>de Vries, LS</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options</title><author>van der Aa, NE ; Benders, MJNL ; Groenendaal, F ; de Vries, LS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4615-138a9db76820553945e06f0bd40b1812a6a2783fd93243f92a0921fd1528751c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cerebral sinovenous thrombosis</topic><topic>Drug therapy</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>MRI</topic><topic>Neonatal stroke</topic><topic>Pathogenesis</topic><topic>Stroke - diagnosis</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>Stroke - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Aa, NE</creatorcontrib><creatorcontrib>Benders, MJNL</creatorcontrib><creatorcontrib>Groenendaal, F</creatorcontrib><creatorcontrib>de Vries, LS</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Aa, NE</au><au>Benders, MJNL</au><au>Groenendaal, F</au><au>de Vries, LS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2014-04</date><risdate>2014</risdate><volume>103</volume><issue>4</issue><spage>356</spage><epage>364</epage><pages>356-364</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Neonatal stroke, including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis, remains a serious problem in the neonate. This article reviews the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options.
Conclusion
Although our understanding of the underlying mechanisms and possible risk factors has improved, little progress has been made towards therapeutic options. Considering the high incidence of neurological sequelae, the need for therapeutic options is high and should be the focus of future research.</abstract><cop>Norway</cop><pub>Blackwell Publishing Ltd</pub><pmid>24428836</pmid><doi>10.1111/apa.12555</doi><tpages>9</tpages></addata></record> |
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| ispartof | Acta Paediatrica, 2014-04, Vol.103 (4), p.356-364 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Cerebral sinovenous thrombosis Drug therapy Epidemiology Humans Infant, Newborn MRI Neonatal stroke Pathogenesis Stroke - diagnosis Stroke - epidemiology Stroke - etiology Stroke - therapy |
| title | Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options |
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