Influence of baseline variables on changes in International Prostate Symptom Score after combined therapy with dutasteride plus tamsulosin or either monotherapy in patients with benign prostatic hyperplasia and lower urinary tract symptoms: 4‐year results of the CombAT study

Objective To examine, using post hoc analysis, the influence of baseline variables on changes in international prostate symptom score (IPSS), maximum urinary flow rate (Qmax) and IPSS quality of life (QoL) in patients with moderate‐to‐severe lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) treated with either the α‐blocker tamsulosin or the dual 5‐alpha reductase inhibitor dutasteride, alone or in combination, as part of the 4‐year Combination of Avodart and Tamsulosin (CombAT) study. Patients and Methods CombAT was a 4‐year, multicentre, randomized, double‐blind, parallel‐group study in 4844 men ≥50 years of age with a clinical diagnosis of BPH by medical history and physical examination, an IPSS ≥12 points, prostate volume (PV) ≥30 mL, total serum PSA level ≥1.5 ng/mL, and Qmax >5 mL/s and ≤15 mL/s with a minimum voided volume ≥125 mL. Eligible subjects were randomized to receive oral daily tamsulosin, 0.4 mg; dutasteride, 0.5 mg; or a combination of both. Baseline variable subgroups analysed were as follows: PV (30 to