Reaction mechanisms of trans-9,10-dihydroxy-anti-7,8-epoxy-7,8,9,10-tetrahydro-3-tetrahyd ro-3-methylcholanthrene with DNA in aqueous solutions. Conformation of adducts

Reaction mechanisms of trans-9,10-dihydroxy-anti-7,8-epoxy-7,8,9,10-tetrahydro-3-tetrahyd ro-3-methylcholanthrene with DNA in aqueous solutions. Conformation of adducts

The reaction mechanisms of trans-0,10-dihyrodxy-anti-7,8-expoxy-7,8,9,10-tetrahydro-3-methylc holanthrene (anti-3-MCDE) in aqueous phosphate buffer solutions (pH 7, 24 degree C) containing double-stranded DNA, and the structure of the covalent adduct formed, were studied by utilizing the techniques...

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Veröffentlicht in:Carcinogenesis (New York) 1986-01, Vol.7 (1), p.41-47
Hauptverfasser: Kim, Myung-Hoon, Geacintov, N E, McQuillen, D G, Pope, M, Harvey, R G
Format: Artikel
Sprache:eng
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Zusammenfassung:The reaction mechanisms of trans-0,10-dihyrodxy-anti-7,8-expoxy-7,8,9,10-tetrahydro-3-methylc holanthrene (anti-3-MCDE) in aqueous phosphate buffer solutions (pH 7, 24 degree C) containing double-stranded DNA, and the structure of the covalent adduct formed, were studied by utilizing the techniques of absorption, fluorescence and linear dichroism spectroscopy. The results were compared with those obtained with the widely studied trans-7,8-dihydroxy-anti-9-10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyr ene (BaPDE).
ISSN:0143-3334