Subarachnoid Hemorrhage: a Review of Experimental Studies on the Microcirculation and the Neurovascular Unit

Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood–brain barrier...

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Veröffentlicht in:	Translational stroke research 2014-04, Vol.5 (2), p.174-189
Hauptverfasser:	Tso, Michael K., Macdonald, R. Loch
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blood-Brain Barrier - physiopathology Brain - blood supply Cardiology Disease Models, Animal Hemorrhage Ischemia Metabolism Microcirculation - physiology Neural networks Neurology Neurosciences Neurosurgery Original Article Pathophysiology Smooth muscle Subarachnoid Hemorrhage - physiopathology Traumatic brain injury Vascular Surgery Vasoconstriction - physiology Veins & arteries
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Beschreibung
Zusammenfassung:	Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood–brain barrier impairment, increased microthrombi, and inversion of neurovascular coupling. This focused review looks at the current state of knowledge regarding the changes that occur in the microcirculation and the neurovascular unit after SAH.
ISSN:	1868-4483 1868-601X
DOI:	10.1007/s12975-014-0323-4