The Z family, a group of transposed human immunoglobulin V sub( Kappa ) genes

A group of highly homologous transposed human V sub( Kappa ) I genes, which the authors call the Z family, was characterized. Hybridization experiments with DNAs from rodent/human cell hybrids and other experimental data indicate that some and possibly all members of the Z family lie outside of the Kappa locus which is located on chromosome 2; they have been transposed to other chromosomes. The authors postulate that the Z family arose by amplification event(s). The Z regions can also be regarded as a small family of very long repetitive sequences.