HIV p24 antigen in brains of children with AIDS: The antigen-containing cell do not react with monoclonal antibody to ILT4 or macrophage markers

HIV p24 antigen in brains of children with AIDS: The antigen-containing cell do not react with monoclonal antibody to ILT4 or macrophage markers

Pediatric AIDS is frequently associated with opportunistic infection of the central nervous system, vacuolar myelopathy, and a subacute encephalopathy. In the latter condition, nucleic acid of HIV has been identified in the brain. The authors now report the detection of HIV p24 antigen (p24Ag) in th...

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Veröffentlicht in:AIDS (London) 1988-01, Vol.2 (5), p.404-405
Hauptverfasser: Pekovic, D D, Lapointe, N, Geoffroy, G, Ajdukovic, D, Michaud, J
Format: Artikel
Sprache:eng
Schlagworte:
human immunodeficiency virus
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Zusammenfassung:Pediatric AIDS is frequently associated with opportunistic infection of the central nervous system, vacuolar myelopathy, and a subacute encephalopathy. In the latter condition, nucleic acid of HIV has been identified in the brain. The authors now report the detection of HIV p24 antigen (p24Ag) in the cerebral cortex and white matter of children with AIDS-related subacute encephalitis. The cells containing p24Ag did not react with monoclonal antibodies (mAb) directed against OKT4 or macrophage markers.
ISSN:0269-9370