Primary cutaneous amyloidosis of the glans penis. Two case reports and a review of the literature

Summary Background Primary cutaneous amyloidosis of the penis is a rare entity. Objectives We describe two cases of primary penile cutaneous amyloidosis presenting as localized lesions on the penis and not associated with systemic amyloidosis. Methods A comprehensive literature review of all published cases. Results The rarest form of cutaneous amyloidosis, nodular amyloidosis, is the most frequent presentation of penis‐limited cutaneous amyloid with a low incidence of systemic disease progression. Conclusions Although primary nodular amyloidosis is a rare entity it seems to be the most frequent presentation of penile‐limited cutaneous disease, with a low incidence of systemic involvement. What's already known about this topic? Primary cutaneous amyloidosis of the penis is a rare entity. Nodular cutaneous amyloid is associated with systemic disease and up to 10% cases with associated paraproteinaemia progress to systemic disease. What does this study add? True penile‐limited cutaneous amyloidosis is highly associated with nodular amyloidosis. Primary cutaneous penile amyloidosis has a low incidence of systemic progression.