Chronic granulomatous disease associated colitis leading to profound zinc deficiency

T-cell function also declines; including decreased production of TH1 cytokines (IFN-γ, IL-2, and TNF).5-7 Acrodermatitis enteropathica is an autosomal recessive genetic defect in zinc absorption that occurs in 1 in 500,000 children.8 It involves the SLC39A gene on chromosome 8q24, which encodes for the Zip4 intestinal zinc transporter, and it presents with a triad of acral and periorificial dermatitis, diarrhea, and alopecia. A review of pediatric patients diagnosed with inflammatory bowel disease revealed zinc deficiency in 40%.4 Our patient was a 3-year-old Pakistani girl born to consanguineous parents, with a mutation of the CYBA gene that affects the p22 phox protein.