Three acetophenones from Acronychia pedunculata

Phytochemical investigation of the leaves and twigs of Acronychia pedunculata has led to the isolation of three new acetophenone monomers 1–3 as well as 1-[2′,4′-dihydroxy-3′,5′-di-(3″-methyl-2″-butenyl)-6′-methoxy]phenylethanone (4), acronyculatin E (5), a mixture of β-sitosterol and stigmasterol, and sesamin. The structures of these new compounds were elucidated spectroscopically. The inhibitory activities of the isolated acetophenone derivatives against mammalian DNA polymerases and human cancer cell growth were also assessed.