Comparison of two commercial vaccines against visceral leishmaniasis in dogs from endemic areas: IgG, and subclasses, parasitism, and parasite transmission by xenodiagnosis

Highlights • Two commercial vaccines against canine visceral leishmaniasis were compared. • The outcome of vaccination of pet dogs was evaluated in endemic natural conditions. • A controlled prospective clinical approach was used to monitor the vaccinated dogs. • Post-vaccinal xenodiagnosis, serolog...

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Veröffentlicht in:	Vaccine 2014-03, Vol.32 (11), p.1287-1295
Hauptverfasser:	Fernandes, Consuelo Barreto, Junior, Jairo Torres Magalhães, de Jesus, Clauceane, Souza, Bárbara Maria Paraná da Silva, Larangeira, Daniela Farias, Fraga, Deborah Bittencourt Mothé, Tavares Veras, Patricia Sampaio, Barrouin-Melo, Stella Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Protozoan - blood Applied microbiology Biological and medical sciences Brazil Canine immunization Dog Diseases - parasitology Dog Diseases - prevention & control Dogs Female Fundamental and applied biological sciences. Psychology Human protozoal diseases Immunity, Humoral Immunoglobulin G - blood Infections Infectious diseases Leishmania infantum Leishmaniasis Vaccines - adverse effects Leishmaniasis Vaccines - therapeutic use Leishmaniasis, Visceral - diagnosis Leishmaniasis, Visceral - prevention & control Leishmaniasis, Visceral - veterinary Leishmune® and Leish-Tec Leshmaniasis Lutzomyia longipalpis Male Medical sciences Microbiology Parasites Parasitic diseases Parasitism Prospective Studies Protozoal diseases Reactogenicity Side effects Vaccination - veterinary Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vector-borne diseases Xenodiagnosis
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Beschreibung
Zusammenfassung:	Highlights • Two commercial vaccines against canine visceral leishmaniasis were compared. • The outcome of vaccination of pet dogs was evaluated in endemic natural conditions. • A controlled prospective clinical approach was used to monitor the vaccinated dogs. • Post-vaccinal xenodiagnosis, serology, parasitology, and clinical data were similar. • Reactogenicity and IgG subclass profile resulted in main differences among vaccines.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.12.046