Sustained functional serotype-specific antibody after primary and secondary vaccinations with a pneumococcal polysaccharide vaccine in elderly patients with chronic lung disease

Highlights • Hyporesponsiveness was inconsistent for opsonic activity after secondary vaccination. • IgG required for 50% killing decreased 1 month after primary vaccination. • IgG required for 50% killing remained low 1 month after secondary vaccination. • Self-limited adverse reactions were more f...

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Veröffentlicht in:	Vaccine 2014-02, Vol.32 (10), p.1181-1186
Hauptverfasser:	Ohshima, Nobuharu, Nagai, Hideaki, Matsui, Hirotoshi, Akashi, Shunsuke, Makino, Tomohiko, Akeda, Yukihiro, Oishi, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Allergy and Immunology Antibodies, Bacterial - blood Antibody Formation Applied microbiology Bacteriology Biological and medical sciences Chronic Disease Female Fundamental and applied biological sciences. Psychology Humans Immunization Immunization, Secondary Immunogenicity Immunoglobulin G - blood Lung Diseases - immunology Male Microbiology Miscellaneous Observational studies Opsonophagocytic activity Pneumococcal Infections - prevention & control Pneumococcal polysaccharide vaccine Pneumococcal Vaccines - adverse effects Pneumococcal Vaccines - therapeutic use Pneumonia Revaccination Serotype-specific IgG Serotyping Streptococcus pneumoniae Streptococcus pneumoniae - classification Studies Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • Hyporesponsiveness was inconsistent for opsonic activity after secondary vaccination. • IgG required for 50% killing decreased 1 month after primary vaccination. • IgG required for 50% killing remained low 1 month after secondary vaccination. • Self-limited adverse reactions were more frequent after secondary vaccination.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.09.060