Development of ‘leaky’ liposome triggered by radiation applicable to a drug reservoir and a simple radiation dosimeter

Radiation effects on permeability of liposomes with different lipid compositions and the content ratios were investigated using X-rays. Liposomes constituted from an unsaturated phosphatidylcholine (PC), a saturated PC, and cholesterol were selected. As a result, we found that a PC with bis-allylic hydrogen, particularly dilinoleoyl PC (DLOPC), is essential for the radiation sensitivity in permeability, and it can be controlled by changing DLOPC content and dose rate. These characteristics are contributive to a novel pharmaceutical and a new-conceptual radiation dosimeter. ► The ‘leaky’ liposome triggered by ionizing radiation was developed. ► The radiation sensitivity can be controlled by changing DLOPC content. ► The liposome is applicable to pharmaceutical and radiation dosimeter.