Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11

Highlights • CXCR3 ligands, CXCL9, CXCL10, and CXCL11, can act as a genetic vaccine adjuvant. • CXCL11 is the strongest vaccine adjuvant among the three CXCR3 ligands. • CXCL11 enhances antigen-specific CD8 T cells responses and memory generation. • CXCL11 enhances vaccine-induced anti-tumor activit...

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Veröffentlicht in:	Vaccine 2014-02, Vol.32 (10), p.1205-1212
Hauptverfasser:	Namkoong, Hong, Song, Mi-Young, Seo, Yong Bok, Choi, Dong-Hoon, Kim, Sae Won, Im, Se Jin, Sung, Young Chul, Park, Yunji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus Adjuvant Adjuvants, Immunologic - genetics Allergy and Immunology Animals Applied microbiology Biological and medical sciences Cancer Vaccines - genetics Cancer Vaccines - immunology CD8 T cell CD8-Positive T-Lymphocytes - immunology Cell Proliferation Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Chemokine CXCL11 - genetics Chemokine CXCL11 - immunology Chemokine CXCL9 - genetics Chemokine CXCL9 - immunology CXCL11 Cytokines - immunology Female Fundamental and applied biological sciences. Psychology HEK293 Cells Human papillomavirus 16 Humans Immune system Immunity, Cellular Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - immunology Immunologic Memory Memory Mice Mice, Inbred C57BL Microbiology Neoplasms, Experimental - therapy Papillomavirus E7 Proteins - immunology Rodents Survival T cell receptors Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral infections
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Beschreibung
Zusammenfassung:	Highlights • CXCR3 ligands, CXCL9, CXCL10, and CXCL11, can act as a genetic vaccine adjuvant. • CXCL11 is the strongest vaccine adjuvant among the three CXCR3 ligands. • CXCL11 enhances antigen-specific CD8 T cells responses and memory generation. • CXCL11 enhances vaccine-induced anti-tumor activities.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.07.066