Passive Movement Improves the Learning and Memory Function of Rats with Cerebral Infarction by Inhibiting Neuron Cell Apoptosis

Passive Movement Improves the Learning and Memory Function of Rats with Cerebral Infarction by Inhibiting Neuron Cell Apoptosis

Passive movement has been found to improve evidently ischemic stroke patients’ impaired capacity of learning and memory, but the optimal time window of initiating the therapy and the underlying mechanism are not fully understood. In this study, the effect of passive movement at different time window...

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Veröffentlicht in:Molecular neurobiology 2014-02, Vol.49 (1), p.216-221
Hauptverfasser: Li, Man, Peng, Jun, Wang, Meng-Die, Song, Yan-Ling, Mei, Yuan-Wu, Fang, Yuan
Format: Artikel
Sprache:eng
Schlagworte:
Animal cognition
Animal memory
Animals
Apoptosis
Apoptosis - physiology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cerebral Infarction - pathology
Cerebral Infarction - physiopathology
Cerebral Infarction - rehabilitation
Exercise Therapy - methods
Learning - physiology
Male
Memory - physiology
Movement - physiology
Neural Inhibition - physiology
Neurobiology
Neurology
Neurons
Neurons - pathology
Neurons - physiology
Neurosciences
Rats
Rats, Sprague-Dawley
Rodents
Time Factors
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Zusammenfassung:Passive movement has been found to improve evidently ischemic stroke patients’ impaired capacity of learning and memory, but the optimal time window of initiating the therapy and the underlying mechanism are not fully understood. In this study, the effect of passive movement at different time windows on learning and memory of rats with cerebral infarction was detected. The results showed that the expression of caspase-3 and escape latency in the passive movement group were all considerably lower than those in the model group ( P  
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-013-8512-9