Synthesis and Antifungal Activity of Arylthiocyanates

Synthesis and Antifungal Activity of Arylthiocyanates

A new method for the synthesis of arylthiocyanates from derivatives of aniline, pyrrole, and indole is described. Products had antimicrobial activity. Dithiocyanates N-methylpyrrole and N-phenylpyrrole were active against Candida albicans , Candida tropicalis , Candida krusei , and Aspergillus niger...

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Veröffentlicht in:Pharmaceutical chemistry journal 2013-11, Vol.47 (8), p.422-425
Hauptverfasser: Kokorekin, V. A., Terent’ev, A. O., Ramenskaya, G. V., Grammatikova, N. É., Rodionova, G. M., Ilovaiskii, A. I.
Format: Artikel
Sprache:eng
Schlagworte:
Aniline
Antibiotics
Aspergillus niger
Candida albicans
Candida krusei
Candida tropicalis
Fluconazole
Medicine
Mycoses
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Thiophene
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Zusammenfassung:A new method for the synthesis of arylthiocyanates from derivatives of aniline, pyrrole, and indole is described. Products had antimicrobial activity. Dithiocyanates N-methylpyrrole and N-phenylpyrrole were active against Candida albicans , Candida tropicalis , Candida krusei , and Aspergillus niger with activity levels comparable to those of fluconazole and amphotericin.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0973-7