Protein tyrosine phosphatase PTP1B in cell adhesion and migration

Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and orga...

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Veröffentlicht in:	Cell adhesion & migration 2013-09, Vol.7 (5), p.418-423
Hauptverfasser:	Arregui, Carlos O, González, Ángela, Burdisso, Juan E, González Wusener, Ana E
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesions Cell Adhesion - genetics Cell Membrane - metabolism Cell Movement - genetics cytoskeleton Cytoskeleton - metabolism endoplasmic reticulum Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Focal Adhesion Kinase 1 - metabolism Humans integrins Integrins - metabolism migration Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism PTP1B rho GTP-Binding Proteins - genetics Signal Transduction Src src-Family Kinases - metabolism α-actinin
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Zusammenfassung:	Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support cell movement. The endoplasmic reticulum-bound protein tyrosine phosphatase PTP1B has been implicated as a regulator of cell adhesion and migration. Recent results from our laboratory shed light on potential mechanisms, such as Src/FAK signaling through Rho GTPases and integrin-cytoskeletal coupling.
ISSN:	1933-6918 1933-6926
DOI:	10.4161/cam.26375