Parathyroid hormone mediates changes in calcium transport in uremic rat brain synaptosomes

In previous studies, the authors showed that Ca super(2+) transport by both Na super(+) gradient-stimulated Ca super(2+) uptake and ATP-stimulated Ca super(2+) uptake was increased in synaptosomes from uremic rat brain. The possible role of parathyroid hormone (PTH) in this observation was investigated by performing Ca super(2+) transport studies in synaptosomes by these two mechanisms. The data suggest that the increased calcium transport observed in synaptosomes from uremic rat brain is mediated by PTH and enhanced by the uremic environment.