Sex influences the effect of body mass index on the vascular response to angiotensin II in humans

Objective Sex influences the cardiorenal risk associated with body mass index (BMI). The role of the renin–angiotensin–aldosterone system in adiposity‐mediated cardiorenal risk profiles in healthy, non‐obese men and women was investigated. Methods Systemic and renal hemodynamic responses to angioten...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2014-03, Vol.22 (3), p.739-746
Hauptverfasser:	Zalucky, A. A., Nicholl, D. D. M., Mann, M. C., Hemmelgarn, B. R., Turin, T. C., MacRae, J. M., Sola, D. Y., Ahmed, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity - drug effects Adult Angiotensin II - pharmacology Blood Pressure - drug effects Body Mass Index Body Weight - drug effects Creatinine - urine Dose-Response Relationship, Drug Female Gender differences Hemodynamics - drug effects Humans Linear Models Male Medical research Men Middle Aged Multivariate Analysis Obesity Obesity - blood Obesity - urine Overweight - blood Overweight - urine Renin-Angiotensin System - drug effects Risk Factors Sex Factors Sodium - urine Sodium, Dietary - administration & dosage Vasoconstrictor Agents - pharmacology Waist Circumference Waist-Hip Ratio Women Young Adult
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Zusammenfassung:	Objective Sex influences the cardiorenal risk associated with body mass index (BMI). The role of the renin–angiotensin–aldosterone system in adiposity‐mediated cardiorenal risk profiles in healthy, non‐obese men and women was investigated. Methods Systemic and renal hemodynamic responses to angiotensin‐II (AngII) as a function of BMI, waist and hip circumference, waist–hip ratio, as well as fat and lean mass were measured in 18 men and 25 women in high‐salt balance, stratified by BMI (
ISSN:	1930-7381 1930-739X
DOI:	10.1002/oby.20608