Bronchial responsiveness in an elastase-induced mouse model of emphysema

Highlights • Methacholine attenuated the airway responsiveness in elastase-induced emphysema in mice. • Collapsed and/or hyperinflated area can modulate parenchymal distortion in such a model. • Elastase levels and thorax conditions are relevant to mechanical evaluations.

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Veröffentlicht in:	Respiratory physiology & neurobiology 2014-04, Vol.194, p.9-14
Hauptverfasser:	Santos, Luiz Marcelo Oliveira, Cervilha, Daniela Aparecida de Brito, Cabral, Layla Dutra Marinho, Garcia, Érika Kristina Incerpi, Teixeira, Vanessa Pereira, Brito, Jôse Mára, Moriya, Henrique Takachi, Soncini, Roseli
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway resistance Animals Bronchoconstrictor Agents Disease Models, Animal Dose-Response Relationship, Drug Elastase Emphysema Emphysema - chemically induced Emphysema - drug therapy Emphysema - physiopathology Hysteresivity Lung - drug effects Lung - pathology Lung - physiopathology Male Medical Education Methacholine Chloride Mice Pancreatic Elastase Pulmonary Alveoli - drug effects Pulmonary Alveoli - pathology Pulmonary Alveoli - physiopathology Pulmonary Atelectasis - drug therapy Pulmonary Atelectasis - physiopathology Pulmonary/Respiratory Respiration, Artificial Respiratory Mechanics - drug effects Thorax - physiopathology
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Zusammenfassung:	Highlights • Methacholine attenuated the airway responsiveness in elastase-induced emphysema in mice. • Collapsed and/or hyperinflated area can modulate parenchymal distortion in such a model. • Elastase levels and thorax conditions are relevant to mechanical evaluations.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2014.01.009