NFκB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFα

Objective Central obesity and sub‐clinical inflammation increase metabolic risk, this study examined the intracellular inflammatory pathways in adipose tissue (AT) that contribute to this risk. Design and Methods This study therefore addressed the influence of NFκB and JNK activation in human abdomi...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2013-11, Vol.21 (11), p.2322-2330
Hauptverfasser:	Harte, Alison L., Tripathi, Gyanendra, Piya, Milan K., Barber, Thomas M., Clapham, John C., Al‐Daghri, Nasser, Al‐Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, Joseph P., Kumar, Sudhesh, McTernan, Philip G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - immunology Adipose Tissue - metabolism Adipose Tissue - pathology Adiposity - physiology Adult Aged Cells, Cultured Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Female Humans Inflammation - genetics Inflammation - metabolism Male Middle Aged Mitogen-Activated Protein Kinase 8 - genetics Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase 9 - genetics Mitogen-Activated Protein Kinase 9 - metabolism NF-kappa B - physiology Panniculitis - genetics Panniculitis - metabolism Recombinant Proteins - pharmacology Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology
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Zusammenfassung:	Objective Central obesity and sub‐clinical inflammation increase metabolic risk, this study examined the intracellular inflammatory pathways in adipose tissue (AT) that contribute to this risk. Design and Methods This study therefore addressed the influence of NFκB and JNK activation in human abdominal subcutaneous (AbdSc) and omental (Om) AT, the effect of adiposity, T2DM status and the role of TNFα in vitro, using molecular biology techniques. Results Our data showed NFκB activity is increased in Om AT versus AbdSc AT (P
ISSN:	1930-7381 1930-739X
DOI:	10.1002/oby.20336