Effectiveness of Novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole Derivatives Against Promastigotes and Amastigotes of Leishmania amazonensis

In this research, a series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI). A series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).