Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior
Objectives DA‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA‐8031 on male sexual behavior in a rat model. Methods Sexual behavior was examined after an acute oral a...
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| Veröffentlicht in: | International journal of urology 2014-03, Vol.21 (3), p.325-329 |
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| container_title | International journal of urology |
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| creator | Kang, Kyung Koo Sung, Ji Hyun Kim, Soon Hoe Lee, Sukhyang |
| description | Objectives
DA‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA‐8031 on male sexual behavior in a rat model.
Methods
Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA‐8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA‐8031 at a dose level of 30 mg/kg.
Results
DA‐8031 treatment produced a dose‐dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle (P |
| doi_str_mv | 10.1111/iju.12256 |
| format | Article |
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DA‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA‐8031 on male sexual behavior in a rat model.
Methods
Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA‐8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA‐8031 at a dose level of 30 mg/kg.
Results
DA‐8031 treatment produced a dose‐dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle (P < 0.05). In addition, DA‐8031 treatment reduced the mean number of ejaculations in a dose‐dependent manner. No changes in post‐ejaculatory interval, numbers of mounts, intromissions or ejaculations were observed at any dose. In pharmacokinetic study, the blood concentration of DA‐8031 peaked at 0.38 ± 0.14 h after oral administration, and then rapidly declined with a half‐life of 1.79 ± 0.32 h.
Conclusions
Treatment with DA‐8031 delays the ejaculation latency time without affecting the initiation of mounting behavior or post‐ejaculatory interval in rats. Furthermore, DA‐8031 is rapidly absorbed and eliminated after oral administration in rats. These preclinical findings provide a clue for the clinical testing of DA‐8031 as an “on‐demand” agent for premature ejaculation.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.12256</identifier><identifier>PMID: 23968141</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Animals ; Benzofurans - pharmacology ; Benzofurans - therapeutic use ; DA-8031 ; Humans ; Male ; premature ejaculation ; Premature Ejaculation - drug therapy ; Rats ; Rats, Sprague-Dawley ; sexual behavior ; Sexual Behavior - drug effects</subject><ispartof>International journal of urology, 2014-03, Vol.21 (3), p.325-329</ispartof><rights>2013 The Japanese Urological Association</rights><rights>2013 The Japanese Urological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4226-969e6fcaab128f88d6d73d6e489e7a1c1f233da8f08675079702959aa57bebd23</citedby><cites>FETCH-LOGICAL-c4226-969e6fcaab128f88d6d73d6e489e7a1c1f233da8f08675079702959aa57bebd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.12256$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.12256$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23968141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Kyung Koo</creatorcontrib><creatorcontrib>Sung, Ji Hyun</creatorcontrib><creatorcontrib>Kim, Soon Hoe</creatorcontrib><creatorcontrib>Lee, Sukhyang</creatorcontrib><title>Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objectives
DA‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA‐8031 on male sexual behavior in a rat model.
Methods
Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA‐8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA‐8031 at a dose level of 30 mg/kg.
Results
DA‐8031 treatment produced a dose‐dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle (P < 0.05). In addition, DA‐8031 treatment reduced the mean number of ejaculations in a dose‐dependent manner. No changes in post‐ejaculatory interval, numbers of mounts, intromissions or ejaculations were observed at any dose. In pharmacokinetic study, the blood concentration of DA‐8031 peaked at 0.38 ± 0.14 h after oral administration, and then rapidly declined with a half‐life of 1.79 ± 0.32 h.
Conclusions
Treatment with DA‐8031 delays the ejaculation latency time without affecting the initiation of mounting behavior or post‐ejaculatory interval in rats. Furthermore, DA‐8031 is rapidly absorbed and eliminated after oral administration in rats. These preclinical findings provide a clue for the clinical testing of DA‐8031 as an “on‐demand” agent for premature ejaculation.</description><subject>Animals</subject><subject>Benzofurans - pharmacology</subject><subject>Benzofurans - therapeutic use</subject><subject>DA-8031</subject><subject>Humans</subject><subject>Male</subject><subject>premature ejaculation</subject><subject>Premature Ejaculation - drug therapy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>sexual behavior</subject><subject>Sexual Behavior - drug effects</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9v1DAQRy0EotvCgS-AfASpaT124j_HqpSlVVkuVBytSTIWWZJ4sZPSfvsGtu2Nuczl_d7hMfYOxAksd9pt5xOQstIv2ArKUhZSlPIlWwkHrrBg5AE7zHkrBCgJ9jU7kMppCyWsmL8IgZqJx8A_nRVWKDjmyMd4Sz2PCXvexGEX57HlISa-SzTgNCfitMVm7nHq4njM48gH7IknnHimu3mZ1fQTb7uY3rBXAftMbx__Ebv5fPH9_Etx_W19eX52XTSllLpw2pEODWIN0gZrW90a1WoqrSOD0ECQSrVog7DaVMI4I6SrHGJlaqpbqY7Yh713l-LvmfLkhy431Pc4Upyzh0qUoLVzYkE_7tEmxZwTBb9L3YDp3oPwf3v6paf_13Nh3z9q53qg9pl8CrgAp3vgT9fT_f9N_vLq5klZ7BddnujueYHpl9dGmcr_2Kz9Gr7qzZXeeKMeAISRjLA</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Kang, Kyung Koo</creator><creator>Sung, Ji Hyun</creator><creator>Kim, Soon Hoe</creator><creator>Lee, Sukhyang</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior</title><author>Kang, Kyung Koo ; Sung, Ji Hyun ; Kim, Soon Hoe ; Lee, Sukhyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4226-969e6fcaab128f88d6d73d6e489e7a1c1f233da8f08675079702959aa57bebd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Benzofurans - pharmacology</topic><topic>Benzofurans - therapeutic use</topic><topic>DA-8031</topic><topic>Humans</topic><topic>Male</topic><topic>premature ejaculation</topic><topic>Premature Ejaculation - drug therapy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>sexual behavior</topic><topic>Sexual Behavior - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Kyung Koo</creatorcontrib><creatorcontrib>Sung, Ji Hyun</creatorcontrib><creatorcontrib>Kim, Soon Hoe</creatorcontrib><creatorcontrib>Lee, Sukhyang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Kyung Koo</au><au>Sung, Ji Hyun</au><au>Kim, Soon Hoe</au><au>Lee, Sukhyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2014-03</date><risdate>2014</risdate><volume>21</volume><issue>3</issue><spage>325</spage><epage>329</epage><pages>325-329</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
DA‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA‐8031 on male sexual behavior in a rat model.
Methods
Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA‐8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA‐8031 at a dose level of 30 mg/kg.
Results
DA‐8031 treatment produced a dose‐dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle (P < 0.05). In addition, DA‐8031 treatment reduced the mean number of ejaculations in a dose‐dependent manner. No changes in post‐ejaculatory interval, numbers of mounts, intromissions or ejaculations were observed at any dose. In pharmacokinetic study, the blood concentration of DA‐8031 peaked at 0.38 ± 0.14 h after oral administration, and then rapidly declined with a half‐life of 1.79 ± 0.32 h.
Conclusions
Treatment with DA‐8031 delays the ejaculation latency time without affecting the initiation of mounting behavior or post‐ejaculatory interval in rats. Furthermore, DA‐8031 is rapidly absorbed and eliminated after oral administration in rats. These preclinical findings provide a clue for the clinical testing of DA‐8031 as an “on‐demand” agent for premature ejaculation.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23968141</pmid><doi>10.1111/iju.12256</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Benzofurans - pharmacology Benzofurans - therapeutic use DA-8031 Humans Male premature ejaculation Premature Ejaculation - drug therapy Rats Rats, Sprague-Dawley sexual behavior Sexual Behavior - drug effects |
| title | Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior |
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