Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior

Objectives DA‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA‐8031 on male sexual behavior in a rat model. Methods Sexual behavior was examined after an acute oral a...

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Veröffentlicht in:International journal of urology 2014-03, Vol.21 (3), p.325-329
Hauptverfasser: Kang, Kyung Koo, Sung, Ji Hyun, Kim, Soon Hoe, Lee, Sukhyang
Format: Artikel
Sprache:eng
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Zusammenfassung:Objectives DA‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA‐8031 on male sexual behavior in a rat model. Methods Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA‐8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA‐8031 at a dose level of 30 mg/kg. Results DA‐8031 treatment produced a dose‐dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle (P 
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.12256