Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis
Not only did the noneosinophilic responders with OA appeared to have a more severe asthma than did eosinophilic responders at the time of diagnosis, but they also had a poorer prognosis than did eosinophilic responders as shown by a greater airflow obstruction, a greater airway hyperresponsiveness,...
Gespeichert in:
| Veröffentlicht in: | Journal of allergy and clinical immunology 2014-03, Vol.133 (3), p.883-885.e3 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 885.e3 |
|---|---|
| container_issue | 3 |
| container_start_page | 883 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 133 |
| creator | Lemiere, Catherine, MD, MSc Chaboillez, Simone, RT Bohadana, Abraham, MD Blais, Lucie, PhD Maghni, Karim, PhD |
| description | Not only did the noneosinophilic responders with OA appeared to have a more severe asthma than did eosinophilic responders at the time of diagnosis, but they also had a poorer prognosis than did eosinophilic responders as shown by a greater airflow obstruction, a greater airway hyperresponsiveness, and a poorer asthma control in spite of a higher dose of inhaled corticosteroids 5 years after diagnosis.  Noneosinophilic responders (n = 15) Eosinophilic responders (n = 29) P value MMP-1 (pg/mL) 78.2 ± 81.2 71.22 ± 75.3 .8 MMP-2 (pg/mL) 1,042.4 ± 1,246.7 832.9 ± 596.9 .5 MMP-3 (pg/mL) 197.1 ± 136.1 269.5 ± 292.9 .4 MMP-8 (pg/mL) 59,824.4 ± 2.1 x 104 58,346.6 ± 5.7 x 104 .9 MMP-9 (pg/mL) 1.4 x 105 ± 1.9 x 105 1.8 x 105 ± 2.6 x 105 .6 MMP-12 (pg/mL) 66.4 ± 33.9 91.9 ± 111.5 .4 TIMP-1 (ng/mL) 119.9 ± 65.6 124.3 ± 69.8 .8 MMP-9/TIMP-1 0.3 ± 0.4 0.5 ± 0.6 .4 IL-4 (pg/mL) 0 ± 0 0.3 ± 1.2 .3 IL-5 (pg/mL) 1.7 ± 3.6 4.0 ± 7.6 .3 IL-13 (pg/mL) 0 ± 0 0.02 ± 0.1 .4 IL-2 (pg/mL) 0.4 ± 0.4 1.0 ± 0.9 .02 IFN-γ (pg/mL) 0.2 ± 0.3 0.5 ± 0.5 .03 IL-8 (pg/mL) 415.9 ± 113.3 475.8 ± 435.2 .6 MCP-3 (pg/mL) 6.9 ± 3.7 10.4 ± 5.7 .04 ICTP (ng/mL) 0.04 ± 0.05 0.04 ± 0.04 .7 PICP (ng/mL) 16.2 ± 32.2 5.7 ± 7.3 .1 Table E2 Inflammatory markers in eosinophilic and noneosinophilic responders assessed at the time of the study ICTP, Carboxyterminal telopeptide of type I collagen; MCP-3, monocyte chemotactic protein-3; MMPs, matrix metalloproteinases; PICP, procollagen type I C peptide; TIMP-1, tissue inhibitor of metalloproteinase-1. |
| doi_str_mv | 10.1016/j.jaci.2013.09.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1504164365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091674913013869</els_id><sourcerecordid>1504164365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-a852f98728b72a5e515931b106eae6096b3a320e8cc3881d56cdc0494e28129a3</originalsourceid><addsrcrecordid>eNp9kt2K1DAUx4Mo7jj6Al5IQYS9aT1JmjQREZbFL1j0Qr0OmfSMk9ppuknrMm_js_hkpszowl5ILkLC73--_oeQpxQqClS-7KrOOl8xoLwCXQGIe2RFQTelVEzcJysATUvZ1PqMPEqpg_zmSj8kZ6ymXCsOK-I_hQFD8kMYd773roiYxjC0GFNx46ddEZybRzv5MNi-sGna7e2r4uL3r3GHQ5gOI-bPFJy3E7ZHhS3GEOKJLcYYvg85QXpMHmxtn_DJ6V6Tb-_efr38UF59fv_x8uKqdILyqbRKsK1WDVObhlmBggrN6YaCRIsStNxwyxmgco4rRVshXeug1jUyRZm2fE3Oj3Fz5usZ02T2Pjnse5sbnZOhAmoqay5FRp_fQbswx9xopmRdN0qoXNOasCPlYkgp4taM0e9tPBgKZjHCdGYxwixGGNAmG5FFz06h580e23-Sv5PPwIsTYJOz_Tbawfl0yymej5aZe33kMM_sp8dokvM4OGx9RDeZNvj_1_Hmjtz1fvA54w88YLrt1yRmwHxZVmbZGMpzECU1_wO-47w4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1644785851</pqid></control><display><type>article</type><title>Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Lemiere, Catherine, MD, MSc ; Chaboillez, Simone, RT ; Bohadana, Abraham, MD ; Blais, Lucie, PhD ; Maghni, Karim, PhD</creator><creatorcontrib>Lemiere, Catherine, MD, MSc ; Chaboillez, Simone, RT ; Bohadana, Abraham, MD ; Blais, Lucie, PhD ; Maghni, Karim, PhD</creatorcontrib><description>Not only did the noneosinophilic responders with OA appeared to have a more severe asthma than did eosinophilic responders at the time of diagnosis, but they also had a poorer prognosis than did eosinophilic responders as shown by a greater airflow obstruction, a greater airway hyperresponsiveness, and a poorer asthma control in spite of a higher dose of inhaled corticosteroids 5 years after diagnosis.  Noneosinophilic responders (n = 15) Eosinophilic responders (n = 29) P value MMP-1 (pg/mL) 78.2 ± 81.2 71.22 ± 75.3 .8 MMP-2 (pg/mL) 1,042.4 ± 1,246.7 832.9 ± 596.9 .5 MMP-3 (pg/mL) 197.1 ± 136.1 269.5 ± 292.9 .4 MMP-8 (pg/mL) 59,824.4 ± 2.1 x 104 58,346.6 ± 5.7 x 104 .9 MMP-9 (pg/mL) 1.4 x 105 ± 1.9 x 105 1.8 x 105 ± 2.6 x 105 .6 MMP-12 (pg/mL) 66.4 ± 33.9 91.9 ± 111.5 .4 TIMP-1 (ng/mL) 119.9 ± 65.6 124.3 ± 69.8 .8 MMP-9/TIMP-1 0.3 ± 0.4 0.5 ± 0.6 .4 IL-4 (pg/mL) 0 ± 0 0.3 ± 1.2 .3 IL-5 (pg/mL) 1.7 ± 3.6 4.0 ± 7.6 .3 IL-13 (pg/mL) 0 ± 0 0.02 ± 0.1 .4 IL-2 (pg/mL) 0.4 ± 0.4 1.0 ± 0.9 .02 IFN-γ (pg/mL) 0.2 ± 0.3 0.5 ± 0.5 .03 IL-8 (pg/mL) 415.9 ± 113.3 475.8 ± 435.2 .6 MCP-3 (pg/mL) 6.9 ± 3.7 10.4 ± 5.7 .04 ICTP (ng/mL) 0.04 ± 0.05 0.04 ± 0.04 .7 PICP (ng/mL) 16.2 ± 32.2 5.7 ± 7.3 .1 Table E2 Inflammatory markers in eosinophilic and noneosinophilic responders assessed at the time of the study ICTP, Carboxyterminal telopeptide of type I collagen; MCP-3, monocyte chemotactic protein-3; MMPs, matrix metalloproteinases; PICP, procollagen type I C peptide; TIMP-1, tissue inhibitor of metalloproteinase-1.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.09.005</identifier><identifier>PMID: 24139830</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Allergy and Immunology ; Asthma ; Asthma, Occupational - immunology ; Asthma, Occupational - physiopathology ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Cross-Sectional Studies ; Female ; Forced Expiratory Volume ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genotype & phenotype ; Humans ; Immunopathology ; Male ; Medical sciences ; Middle Aged ; Nitric oxide ; Phenotype ; Pneumology ; Prognosis ; Quality of Life ; Questionnaires ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><ispartof>Journal of allergy and clinical immunology, 2014-03, Vol.133 (3), p.883-885.e3</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2013 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Limited Mar 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-a852f98728b72a5e515931b106eae6096b3a320e8cc3881d56cdc0494e28129a3</citedby><cites>FETCH-LOGICAL-c513t-a852f98728b72a5e515931b106eae6096b3a320e8cc3881d56cdc0494e28129a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2013.09.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28383896$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24139830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lemiere, Catherine, MD, MSc</creatorcontrib><creatorcontrib>Chaboillez, Simone, RT</creatorcontrib><creatorcontrib>Bohadana, Abraham, MD</creatorcontrib><creatorcontrib>Blais, Lucie, PhD</creatorcontrib><creatorcontrib>Maghni, Karim, PhD</creatorcontrib><title>Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Not only did the noneosinophilic responders with OA appeared to have a more severe asthma than did eosinophilic responders at the time of diagnosis, but they also had a poorer prognosis than did eosinophilic responders as shown by a greater airflow obstruction, a greater airway hyperresponsiveness, and a poorer asthma control in spite of a higher dose of inhaled corticosteroids 5 years after diagnosis.  Noneosinophilic responders (n = 15) Eosinophilic responders (n = 29) P value MMP-1 (pg/mL) 78.2 ± 81.2 71.22 ± 75.3 .8 MMP-2 (pg/mL) 1,042.4 ± 1,246.7 832.9 ± 596.9 .5 MMP-3 (pg/mL) 197.1 ± 136.1 269.5 ± 292.9 .4 MMP-8 (pg/mL) 59,824.4 ± 2.1 x 104 58,346.6 ± 5.7 x 104 .9 MMP-9 (pg/mL) 1.4 x 105 ± 1.9 x 105 1.8 x 105 ± 2.6 x 105 .6 MMP-12 (pg/mL) 66.4 ± 33.9 91.9 ± 111.5 .4 TIMP-1 (ng/mL) 119.9 ± 65.6 124.3 ± 69.8 .8 MMP-9/TIMP-1 0.3 ± 0.4 0.5 ± 0.6 .4 IL-4 (pg/mL) 0 ± 0 0.3 ± 1.2 .3 IL-5 (pg/mL) 1.7 ± 3.6 4.0 ± 7.6 .3 IL-13 (pg/mL) 0 ± 0 0.02 ± 0.1 .4 IL-2 (pg/mL) 0.4 ± 0.4 1.0 ± 0.9 .02 IFN-γ (pg/mL) 0.2 ± 0.3 0.5 ± 0.5 .03 IL-8 (pg/mL) 415.9 ± 113.3 475.8 ± 435.2 .6 MCP-3 (pg/mL) 6.9 ± 3.7 10.4 ± 5.7 .04 ICTP (ng/mL) 0.04 ± 0.05 0.04 ± 0.04 .7 PICP (ng/mL) 16.2 ± 32.2 5.7 ± 7.3 .1 Table E2 Inflammatory markers in eosinophilic and noneosinophilic responders assessed at the time of the study ICTP, Carboxyterminal telopeptide of type I collagen; MCP-3, monocyte chemotactic protein-3; MMPs, matrix metalloproteinases; PICP, procollagen type I C peptide; TIMP-1, tissue inhibitor of metalloproteinase-1.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Asthma</subject><subject>Asthma, Occupational - immunology</subject><subject>Asthma, Occupational - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Phenotype</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt2K1DAUx4Mo7jj6Al5IQYS9aT1JmjQREZbFL1j0Qr0OmfSMk9ppuknrMm_js_hkpszowl5ILkLC73--_oeQpxQqClS-7KrOOl8xoLwCXQGIe2RFQTelVEzcJysATUvZ1PqMPEqpg_zmSj8kZ6ymXCsOK-I_hQFD8kMYd773roiYxjC0GFNx46ddEZybRzv5MNi-sGna7e2r4uL3r3GHQ5gOI-bPFJy3E7ZHhS3GEOKJLcYYvg85QXpMHmxtn_DJ6V6Tb-_efr38UF59fv_x8uKqdILyqbRKsK1WDVObhlmBggrN6YaCRIsStNxwyxmgco4rRVshXeug1jUyRZm2fE3Oj3Fz5usZ02T2Pjnse5sbnZOhAmoqay5FRp_fQbswx9xopmRdN0qoXNOasCPlYkgp4taM0e9tPBgKZjHCdGYxwixGGNAmG5FFz06h580e23-Sv5PPwIsTYJOz_Tbawfl0yymej5aZe33kMM_sp8dokvM4OGx9RDeZNvj_1_Hmjtz1fvA54w88YLrt1yRmwHxZVmbZGMpzECU1_wO-47w4</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Lemiere, Catherine, MD, MSc</creator><creator>Chaboillez, Simone, RT</creator><creator>Bohadana, Abraham, MD</creator><creator>Blais, Lucie, PhD</creator><creator>Maghni, Karim, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis</title><author>Lemiere, Catherine, MD, MSc ; Chaboillez, Simone, RT ; Bohadana, Abraham, MD ; Blais, Lucie, PhD ; Maghni, Karim, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-a852f98728b72a5e515931b106eae6096b3a320e8cc3881d56cdc0494e28129a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Asthma</topic><topic>Asthma, Occupational - immunology</topic><topic>Asthma, Occupational - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Phenotype</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lemiere, Catherine, MD, MSc</creatorcontrib><creatorcontrib>Chaboillez, Simone, RT</creatorcontrib><creatorcontrib>Bohadana, Abraham, MD</creatorcontrib><creatorcontrib>Blais, Lucie, PhD</creatorcontrib><creatorcontrib>Maghni, Karim, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lemiere, Catherine, MD, MSc</au><au>Chaboillez, Simone, RT</au><au>Bohadana, Abraham, MD</au><au>Blais, Lucie, PhD</au><au>Maghni, Karim, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>133</volume><issue>3</issue><spage>883</spage><epage>885.e3</epage><pages>883-885.e3</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Not only did the noneosinophilic responders with OA appeared to have a more severe asthma than did eosinophilic responders at the time of diagnosis, but they also had a poorer prognosis than did eosinophilic responders as shown by a greater airflow obstruction, a greater airway hyperresponsiveness, and a poorer asthma control in spite of a higher dose of inhaled corticosteroids 5 years after diagnosis.  Noneosinophilic responders (n = 15) Eosinophilic responders (n = 29) P value MMP-1 (pg/mL) 78.2 ± 81.2 71.22 ± 75.3 .8 MMP-2 (pg/mL) 1,042.4 ± 1,246.7 832.9 ± 596.9 .5 MMP-3 (pg/mL) 197.1 ± 136.1 269.5 ± 292.9 .4 MMP-8 (pg/mL) 59,824.4 ± 2.1 x 104 58,346.6 ± 5.7 x 104 .9 MMP-9 (pg/mL) 1.4 x 105 ± 1.9 x 105 1.8 x 105 ± 2.6 x 105 .6 MMP-12 (pg/mL) 66.4 ± 33.9 91.9 ± 111.5 .4 TIMP-1 (ng/mL) 119.9 ± 65.6 124.3 ± 69.8 .8 MMP-9/TIMP-1 0.3 ± 0.4 0.5 ± 0.6 .4 IL-4 (pg/mL) 0 ± 0 0.3 ± 1.2 .3 IL-5 (pg/mL) 1.7 ± 3.6 4.0 ± 7.6 .3 IL-13 (pg/mL) 0 ± 0 0.02 ± 0.1 .4 IL-2 (pg/mL) 0.4 ± 0.4 1.0 ± 0.9 .02 IFN-γ (pg/mL) 0.2 ± 0.3 0.5 ± 0.5 .03 IL-8 (pg/mL) 415.9 ± 113.3 475.8 ± 435.2 .6 MCP-3 (pg/mL) 6.9 ± 3.7 10.4 ± 5.7 .04 ICTP (ng/mL) 0.04 ± 0.05 0.04 ± 0.04 .7 PICP (ng/mL) 16.2 ± 32.2 5.7 ± 7.3 .1 Table E2 Inflammatory markers in eosinophilic and noneosinophilic responders assessed at the time of the study ICTP, Carboxyterminal telopeptide of type I collagen; MCP-3, monocyte chemotactic protein-3; MMPs, matrix metalloproteinases; PICP, procollagen type I C peptide; TIMP-1, tissue inhibitor of metalloproteinase-1.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>24139830</pmid><doi>10.1016/j.jaci.2013.09.005</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2014-03, Vol.133 (3), p.883-885.e3 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1504164365 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Allergy and Immunology Asthma Asthma, Occupational - immunology Asthma, Occupational - physiopathology Biological and medical sciences Chronic obstructive pulmonary disease, asthma Cross-Sectional Studies Female Forced Expiratory Volume Fundamental and applied biological sciences. Psychology Fundamental immunology Genotype & phenotype Humans Immunopathology Male Medical sciences Middle Aged Nitric oxide Phenotype Pneumology Prognosis Quality of Life Questionnaires Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T08%3A02%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Noneosinophilic%20responders%20with%20occupational%20asthma:%20A%C2%A0phenotype%20associated%20with%20a%20poor%20asthma%20prognosis&rft.jtitle=Journal%20of%20allergy%20and%20clinical%20immunology&rft.au=Lemiere,%20Catherine,%20MD,%20MSc&rft.date=2014-03-01&rft.volume=133&rft.issue=3&rft.spage=883&rft.epage=885.e3&rft.pages=883-885.e3&rft.issn=0091-6749&rft.eissn=1097-6825&rft.coden=JACIBY&rft_id=info:doi/10.1016/j.jaci.2013.09.005&rft_dat=%3Cproquest_cross%3E1504164365%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1644785851&rft_id=info:pmid/24139830&rft_els_id=S0091674913013869&rfr_iscdi=true |