Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis

Not only did the noneosinophilic responders with OA appeared to have a more severe asthma than did eosinophilic responders at the time of diagnosis, but they also had a poorer prognosis than did eosinophilic responders as shown by a greater airflow obstruction, a greater airway hyperresponsiveness, and a poorer asthma control in spite of a higher dose of inhaled corticosteroids 5 years after diagnosis.  Noneosinophilic responders (n = 15) Eosinophilic responders (n = 29) P value MMP-1 (pg/mL) 78.2 ± 81.2 71.22 ± 75.3 .8 MMP-2 (pg/mL) 1,042.4 ± 1,246.7 832.9 ± 596.9 .5 MMP-3 (pg/mL) 197.1 ± 136.1 269.5 ± 292.9 .4 MMP-8 (pg/mL) 59,824.4 ± 2.1 x 104 58,346.6 ± 5.7 x 104 .9 MMP-9 (pg/mL) 1.4 x 105 ± 1.9 x 105 1.8 x 105 ± 2.6 x 105 .6 MMP-12 (pg/mL) 66.4 ± 33.9 91.9 ± 111.5 .4 TIMP-1 (ng/mL) 119.9 ± 65.6 124.3 ± 69.8 .8 MMP-9/TIMP-1 0.3 ± 0.4 0.5 ± 0.6 .4 IL-4 (pg/mL) 0 ± 0 0.3 ± 1.2 .3 IL-5 (pg/mL) 1.7 ± 3.6 4.0 ± 7.6 .3 IL-13 (pg/mL) 0 ± 0 0.02 ± 0.1 .4 IL-2 (pg/mL) 0.4 ± 0.4 1.0 ± 0.9 .02 IFN-γ (pg/mL) 0.2 ± 0.3 0.5 ± 0.5 .03 IL-8 (pg/mL) 415.9 ± 113.3 475.8 ± 435.2 .6 MCP-3 (pg/mL) 6.9 ± 3.7 10.4 ± 5.7 .04 ICTP (ng/mL) 0.04 ± 0.05 0.04 ± 0.04 .7 PICP (ng/mL) 16.2 ± 32.2 5.7 ± 7.3 .1 Table E2 Inflammatory markers in eosinophilic and noneosinophilic responders assessed at the time of the study ICTP, Carboxyterminal telopeptide of type I collagen; MCP-3, monocyte chemotactic protein-3; MMPs, matrix metalloproteinases; PICP, procollagen type I C peptide; TIMP-1, tissue inhibitor of metalloproteinase-1.