Changes in the brain and plasma Aβ peptide levels with age and its relationship with cognitive impairment in the APPswe/PS1dE9 mouse model of Alzheimer’s disease

Highlights • Amyloid β deposits appear in 3-month-old APPswe/PS1dE9 mice. • Amyloid deposition was accompanied by a fall in soluble and membrane-bound Aβ levels. • Insoluble levels of Aβ peptides in the brain correlate inversely with plasma Aβ levels. • Plasma Aβ levels could be developed as possibl...

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Veröffentlicht in:	Neuroscience 2014-03, Vol.263, p.269-279
Hauptverfasser:	Izco, M, Martínez, P, Corrales, A, Fandos, N, García, S, Insua, D, Montañes, M, Pérez-Grijalba, V, Rueda, N, Vidal, V, Martínez-Cué, C, Pesini, P, Sarasa, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Age Factors Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Amyloid beta-Peptides - blood Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Animals Biological and medical sciences Brain - metabolism Brain - pathology Cognition Disorders - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Male Maze Learning - physiology Medical sciences Memory Disorders - metabolism Mice Mice, Transgenic Neurology Organic mental disorders. Neuropsychology Presenilin-1 - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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Zusammenfassung:	Highlights • Amyloid β deposits appear in 3-month-old APPswe/PS1dE9 mice. • Amyloid deposition was accompanied by a fall in soluble and membrane-bound Aβ levels. • Insoluble levels of Aβ peptides in the brain correlate inversely with plasma Aβ levels. • Plasma Aβ levels could be developed as possible biomarkers of cerebral amyloidosis in transgenic mice of AD.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.01.003