GABAergic synaptic transmission onto striatal cholinergic interneurons in dopamine D2 receptor knock-out mice

Highlights • We used dopamine D2 receptor knock-out mice. • We examined frequency-dependent suppression of striatal inhibitory transmission. • Physiologically released dopamine modulates synaptic transmission and neuronal firing. • Modulation of transmission by dopamine is tightly coupled to N-type...

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Veröffentlicht in:	Neuroscience 2014-03, Vol.263, p.138-147
Hauptverfasser:	Sato, A, Sasaoka, T, Nishijo, T, Momiyama, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Channels, N-Type - metabolism Cholinergic Neurons - physiology Corpus Striatum - physiology Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Inhibitory Postsynaptic Potentials Interneurons - physiology Mice Mice, Inbred C57BL Mice, Knockout Neurology Receptors, Dopamine D2 - genetics Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • We used dopamine D2 receptor knock-out mice. • We examined frequency-dependent suppression of striatal inhibitory transmission. • Physiologically released dopamine modulates synaptic transmission and neuronal firing. • Modulation of transmission by dopamine is tightly coupled to N-type calcium channels.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.01.010