Are serum suPAR determinations by current ELISA methodology reliable diagnostic biomarkers for FSGS?

A soluble proteinuric substance has been postulated as a cause of primary focal segmental glomerulosclerosis (FSGS), and one candidate soluble urokinase receptor (suPAR). Evaluation of published results shows that serum suPAR determinations by current methodology do not reliably distinguish FSGS fro...

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Veröffentlicht in:	Kidney international 2014-03, Vol.85 (3), p.499-501
1. Verfasser:	Schlöndorff, Detlef
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Glomerulonephritis - blood Glomerulosclerosis, Focal Segmental - blood Glomerulosclerosis, Focal Segmental - diagnosis Humans Male Nephrotic Syndrome - blood Receptors, Urokinase Plasminogen Activator - blood Receptors, Urokinase Plasminogen Activator - physiology
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Zusammenfassung:	A soluble proteinuric substance has been postulated as a cause of primary focal segmental glomerulosclerosis (FSGS), and one candidate soluble urokinase receptor (suPAR). Evaluation of published results shows that serum suPAR determinations by current methodology do not reliably distinguish FSGS from other proteinuric glomerular diseases and serum suPAR cannot currently be considered a valid biomarker for primary or secondary FSGS. However, this should not discourage further research on potential roles of suPAR in proteinuric renal disease, including FSGS.
ISSN:	0085-2538 1523-1755
DOI:	10.1038/ki.2013.549