Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment
Highlights • HIV-1 viremia significantly increases Ki-67, CD57, and CD95 expressions in CD4+ CD31+ naïve T cells. • 37.5% of IR fail to restored the numbers of CD4+ CD31+ naïve T cells. • CD57 and CD95 expressions are significantly associated with reconstitution failure of CD4+ CD31+ naïve T cells i...
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| Veröffentlicht in: | Immunology letters 2014-03, Vol.158 (1), p.1-6 |
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| container_title | Immunology letters |
| container_volume | 158 |
| creator | Lu, I Eberhard, J Ahmad, F Bhatnagar, N Behrens, G Jacobs, R Schmidt, R.E Meyer-Olson, D |
| description | Highlights • HIV-1 viremia significantly increases Ki-67, CD57, and CD95 expressions in CD4+ CD31+ naïve T cells. • 37.5% of IR fail to restored the numbers of CD4+ CD31+ naïve T cells. • CD57 and CD95 expressions are significantly associated with reconstitution failure of CD4+ CD31+ naïve T cells in IR. |
| doi_str_mv | 10.1016/j.imlet.2013.11.014 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-21135ebd3ea1ba87f9a569bd252e64d13dd3a0ed8253481cf9e33b171f6104593</citedby><cites>FETCH-LOGICAL-c414t-21135ebd3ea1ba87f9a569bd252e64d13dd3a0ed8253481cf9e33b171f6104593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016524781300196X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24291117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, I</creatorcontrib><creatorcontrib>Eberhard, J</creatorcontrib><creatorcontrib>Ahmad, F</creatorcontrib><creatorcontrib>Bhatnagar, N</creatorcontrib><creatorcontrib>Behrens, G</creatorcontrib><creatorcontrib>Jacobs, R</creatorcontrib><creatorcontrib>Schmidt, R.E</creatorcontrib><creatorcontrib>Meyer-Olson, D</creatorcontrib><title>Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Highlights • HIV-1 viremia significantly increases Ki-67, CD57, and CD95 expressions in CD4+ CD31+ naïve T cells. • 37.5% of IR fail to restored the numbers of CD4+ CD31+ naïve T cells. • CD57 and CD95 expressions are significantly associated with reconstitution failure of CD4+ CD31+ naïve T cells in IR.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Biomarkers, Pharmacological - metabolism</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>CD57 Antigens - genetics</subject><subject>CD57 Antigens - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>fas Receptor - genetics</subject><subject>fas Receptor - metabolism</subject><subject>Female</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV-1</subject><subject>HIV-1 - immunology</subject><subject>Humans</subject><subject>Immune responders</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - metabolism</subject><subject>Recent thymic emigrants</subject><subject>T-Lymphocyte Subsets - drug effects</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - virology</subject><subject>Thymus Gland - immunology</subject><subject>Up-Regulation</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAUjBCILoVfgIR8REIJfrG9SQ4goaXQSpU48CFulmO_tF4Se2s7W_Y38SdxuoUDF05-h5l5fjNTFM-BVkBh_Xpb2WnEVNUUWAVQUeAPihW0TVdSweuHxSqjRFnzpj0pnsS4pRQE4-xxcVLzugOAZlX8OhtxrxIasnkvGqLcMnSC4M9dwBitd5GogETF6LW9A97adE1Gf4uBuHnqMUTih8zir0hAjS6RdH2YrCY42augXIrEOnJ-8a2EPAyoFxE7TbPDTIg778yiMfgxi1p3lT-RbMAU_N4GNZIUUKUp6z4tHg1qjPjs_j0tvn44-7I5Ly8_fbzYvLssNQeeyhqACewNQwW9apuhU2Ld9aYWNa65AWYMUxRNW2c3WtBDh4z10MCwBspFx06Ll0fdXfA3M8YkJxs1jqNy6OcoQdC8CETLM5QdoTr4GAMOchfspMJBApVLSnIr71KSS0oSQOaUMuvF_YK5n9D85fyJJQPeHAGYz9xbDDJqi06jycboJI23_1nw9h--Hq2zWo0_8IBx6-fgsoMSZKwllZ-Xoiw9AZY70q2_s9-C5rss</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Lu, I</creator><creator>Eberhard, J</creator><creator>Ahmad, F</creator><creator>Bhatnagar, N</creator><creator>Behrens, G</creator><creator>Jacobs, R</creator><creator>Schmidt, R.E</creator><creator>Meyer-Olson, D</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment</title><author>Lu, I ; Eberhard, J ; Ahmad, F ; Bhatnagar, N ; Behrens, G ; Jacobs, R ; Schmidt, R.E ; Meyer-Olson, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-21135ebd3ea1ba87f9a569bd252e64d13dd3a0ed8253481cf9e33b171f6104593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Anti-Retroviral Agents - therapeutic use</topic><topic>Biomarkers, Pharmacological - metabolism</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>CD57 Antigens - genetics</topic><topic>CD57 Antigens - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>fas Receptor - genetics</topic><topic>fas Receptor - metabolism</topic><topic>Female</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV-1</topic><topic>HIV-1 - immunology</topic><topic>Humans</topic><topic>Immune responders</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - metabolism</topic><topic>Recent thymic emigrants</topic><topic>T-Lymphocyte Subsets - drug effects</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - virology</topic><topic>Thymus Gland - immunology</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, I</creatorcontrib><creatorcontrib>Eberhard, J</creatorcontrib><creatorcontrib>Ahmad, F</creatorcontrib><creatorcontrib>Bhatnagar, N</creatorcontrib><creatorcontrib>Behrens, G</creatorcontrib><creatorcontrib>Jacobs, R</creatorcontrib><creatorcontrib>Schmidt, R.E</creatorcontrib><creatorcontrib>Meyer-Olson, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, I</au><au>Eberhard, J</au><au>Ahmad, F</au><au>Bhatnagar, N</au><au>Behrens, G</au><au>Jacobs, R</au><au>Schmidt, R.E</au><au>Meyer-Olson, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>158</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>Highlights • HIV-1 viremia significantly increases Ki-67, CD57, and CD95 expressions in CD4+ CD31+ naïve T cells. • 37.5% of IR fail to restored the numbers of CD4+ CD31+ naïve T cells. • CD57 and CD95 expressions are significantly associated with reconstitution failure of CD4+ CD31+ naïve T cells in IR.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24291117</pmid><doi>10.1016/j.imlet.2013.11.014</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Immunology letters, 2014-03, Vol.158 (1), p.1-6 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Allergy and Immunology Anti-Retroviral Agents - therapeutic use Biomarkers, Pharmacological - metabolism CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD57 Antigens - genetics CD57 Antigens - metabolism Cross-Sectional Studies Disease Progression fas Receptor - genetics fas Receptor - metabolism Female HIV Infections - drug therapy HIV Infections - immunology HIV-1 HIV-1 - immunology Humans Immune responders Lymphocyte Count Male Middle Aged Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Recent thymic emigrants T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology Thymus Gland - immunology Up-Regulation |
| title | Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment |
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