Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment

Highlights • HIV-1 viremia significantly increases Ki-67, CD57, and CD95 expressions in CD4+ CD31+ naïve T cells. • 37.5% of IR fail to restored the numbers of CD4+ CD31+ naïve T cells. • CD57 and CD95 expressions are significantly associated with reconstitution failure of CD4+ CD31+ naïve T cells i...

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Veröffentlicht in:	Immunology letters 2014-03, Vol.158 (1), p.1-6
Hauptverfasser:	Lu, I, Eberhard, J, Ahmad, F, Bhatnagar, N, Behrens, G, Jacobs, R, Schmidt, R.E, Meyer-Olson, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergy and Immunology Anti-Retroviral Agents - therapeutic use Biomarkers, Pharmacological - metabolism CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD57 Antigens - genetics CD57 Antigens - metabolism Cross-Sectional Studies Disease Progression fas Receptor - genetics fas Receptor - metabolism Female HIV Infections - drug therapy HIV Infections - immunology HIV-1 HIV-1 - immunology Humans Immune responders Lymphocyte Count Male Middle Aged Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Recent thymic emigrants T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology Thymus Gland - immunology Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights • HIV-1 viremia significantly increases Ki-67, CD57, and CD95 expressions in CD4+ CD31+ naïve T cells. • 37.5% of IR fail to restored the numbers of CD4+ CD31+ naïve T cells. • CD57 and CD95 expressions are significantly associated with reconstitution failure of CD4+ CD31+ naïve T cells in IR.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2013.11.014