Iridal-Type Triterpenoids with Neuroprotective Activities from Iris tectorum

Six novel iridal-type triterpenoids with a previously unreported 3,6-dihydro-2H-pyran moiety, named spirioiridotectals A–F (1–6), were isolated from the ethanol extract of the rhizomes of Iris tectorum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Furthermore, i...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-02, Vol.77 (2), p.411-415
Hauptverfasser:	Zhang, Chun-Lei, Wang, Yan, Liu, Yan-Fei, Ni, Gang, Liang, Dong, Luo, Huan, Song, Xiu-Yun, Zhang, Wan-Qing, Chen, Ruo-Yun, Chen, Nai-Hong, Yu, De-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Iridaceae - chemistry Molecular Structure Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Nuclear Magnetic Resonance, Biomolecular PC12 Cells Rats Rhizome - chemistry Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Beschreibung
Zusammenfassung:	Six novel iridal-type triterpenoids with a previously unreported 3,6-dihydro-2H-pyran moiety, named spirioiridotectals A–F (1–6), were isolated from the ethanol extract of the rhizomes of Iris tectorum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Furthermore, in in vitro bioactivity assays, compounds 1, 2, and 6 exhibited neuroprotective activities against serum-deprivation-induced PC12 cell damage.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np400937f