Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells
A Fab‐ulous killer: An anti‐CD3 Fab‐folate conjugate that targets cytotoxic T cells to folate‐receptor‐positive (FR+) tumors results in efficient killing of tumor cells by activated T cells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12101-12104 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Kularatne, Sumith A. Deshmukh, Vishal Gymnopoulos, Marco Biroc, Sandra L. Xia, Jinming Srinagesh, Shailaja Sun, Ying Zou, Ning Shimazu, Mark Pinkstaff, Jason Ensari, Semsi Knudsen, Nick Manibusan, Anthony Axup, Jun Y. Kim, Chan Hyuk Smider, Vaughn V. Javahishvili, Tsotne Schultz, Peter G. |
| description | A Fab‐ulous killer: An anti‐CD3 Fab‐folate conjugate that targets cytotoxic T cells to folate‐receptor‐positive (FR+) tumors results in efficient killing of tumor cells by activated T cells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal chemical reactivity affords homogenous conjugates with precise control over the relative geometry of the antibody binding sites in excellent yields. |
| doi_str_mv | 10.1002/anie.201306866 |
| format | Article |
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This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal chemical reactivity affords homogenous conjugates with precise control over the relative geometry of the antibody binding sites in excellent yields.</description><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201306866</identifier><identifier>PMID: 24573789</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; bispecific antibody ; cancer ; CD3 Complex - immunology ; Cell Line, Tumor ; Coculture Techniques ; folate receptor ; Folate Receptors, GPI-Anchored - metabolism ; Folic Acid - chemistry ; Humans ; Immunoglobulin Fab Fragments - chemistry ; Immunoglobulin Fab Fragments - immunology ; Immunoglobulin Fc Fragments - chemistry ; Immunoglobulin Fc Fragments - immunology ; Immunoglobulin G - chemistry ; Immunoglobulin G - immunology ; Immunotherapy ; Leukocytes, Mononuclear - cytology ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasms - metabolism ; Neoplasms - pathology ; Neoplasms - therapy ; Rats ; Rats, Sprague-Dawley ; T cells ; T-Lymphocytes, Cytotoxic - cytology ; T-Lymphocytes, Cytotoxic - immunology</subject><ispartof>Angewandte Chemie International Edition, 2013-11, Vol.52 (46), p.12101-12104</ispartof><rights>Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4606-e3994d00081448e54d2c867815cf83c97aa563898998d1319a56911d05499cc53</citedby><cites>FETCH-LOGICAL-c4606-e3994d00081448e54d2c867815cf83c97aa563898998d1319a56911d05499cc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201306866$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201306866$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24573789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kularatne, Sumith A.</creatorcontrib><creatorcontrib>Deshmukh, Vishal</creatorcontrib><creatorcontrib>Gymnopoulos, Marco</creatorcontrib><creatorcontrib>Biroc, Sandra L.</creatorcontrib><creatorcontrib>Xia, Jinming</creatorcontrib><creatorcontrib>Srinagesh, Shailaja</creatorcontrib><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Zou, Ning</creatorcontrib><creatorcontrib>Shimazu, Mark</creatorcontrib><creatorcontrib>Pinkstaff, Jason</creatorcontrib><creatorcontrib>Ensari, Semsi</creatorcontrib><creatorcontrib>Knudsen, Nick</creatorcontrib><creatorcontrib>Manibusan, Anthony</creatorcontrib><creatorcontrib>Axup, Jun Y.</creatorcontrib><creatorcontrib>Kim, Chan Hyuk</creatorcontrib><creatorcontrib>Smider, Vaughn V.</creatorcontrib><creatorcontrib>Javahishvili, Tsotne</creatorcontrib><creatorcontrib>Schultz, Peter G.</creatorcontrib><title>Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>A Fab‐ulous killer: An anti‐CD3 Fab‐folate conjugate that targets cytotoxic T cells to folate‐receptor‐positive (FR+) tumors results in efficient killing of tumor cells by activated T cells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal chemical reactivity affords homogenous conjugates with precise control over the relative geometry of the antibody binding sites in excellent yields.</description><subject>Animals</subject><subject>bispecific antibody</subject><subject>cancer</subject><subject>CD3 Complex - immunology</subject><subject>Cell Line, Tumor</subject><subject>Coculture Techniques</subject><subject>folate receptor</subject><subject>Folate Receptors, GPI-Anchored - metabolism</subject><subject>Folic Acid - chemistry</subject><subject>Humans</subject><subject>Immunoglobulin Fab Fragments - chemistry</subject><subject>Immunoglobulin Fab Fragments - immunology</subject><subject>Immunoglobulin Fc Fragments - chemistry</subject><subject>Immunoglobulin Fc Fragments - immunology</subject><subject>Immunoglobulin G - chemistry</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunotherapy</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Mice, SCID</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>T cells</subject><subject>T-Lymphocytes, Cytotoxic - cytology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFPwjAYhhujEUSvHs2OXobtunbtkSyAGDKNYPTW1K6Y6aDYbgo3L_5Rf4nFIfHm4Uu_Js_75MsLwCmCXQRhdCEXhe5GEGFIGaV7oI1IhEKcJHjf7zHGYcIIaoEj5549zxikh6AVxSTBCeNtMLzVytZFVSyegnRdmcqsChVMvz4-U12WLqhMMDClrHToQb2sjA1vjPP8mw5SuVDaBj_gMTiYydLpk-3bAXeD_jS9DMfXw1HaG4cqppCGGnMe5xBChuKYaRLnkWI0YYioGcOKJ1ISihlnnLMcYcT9lyOUQxJzrhTBHXDeeJfWvNbaVWJeOOUvkAttaicQgZj4Ydyj3QZV1jhn9UwsbTGXdi0QFJvyxKY8sSvPB8627vpxrvMd_tuWB3gDvBelXv-jE71s1P8rD5ts4Sq92mWlfRHU24m4z4ZicoWzhwwTMcHfSnaJaw</recordid><startdate>20131111</startdate><enddate>20131111</enddate><creator>Kularatne, Sumith A.</creator><creator>Deshmukh, Vishal</creator><creator>Gymnopoulos, Marco</creator><creator>Biroc, Sandra L.</creator><creator>Xia, Jinming</creator><creator>Srinagesh, Shailaja</creator><creator>Sun, Ying</creator><creator>Zou, Ning</creator><creator>Shimazu, Mark</creator><creator>Pinkstaff, Jason</creator><creator>Ensari, Semsi</creator><creator>Knudsen, Nick</creator><creator>Manibusan, Anthony</creator><creator>Axup, Jun Y.</creator><creator>Kim, Chan Hyuk</creator><creator>Smider, Vaughn V.</creator><creator>Javahishvili, Tsotne</creator><creator>Schultz, Peter G.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131111</creationdate><title>Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells</title><author>Kularatne, Sumith A. ; Deshmukh, Vishal ; Gymnopoulos, Marco ; Biroc, Sandra L. ; Xia, Jinming ; Srinagesh, Shailaja ; Sun, Ying ; Zou, Ning ; Shimazu, Mark ; Pinkstaff, Jason ; Ensari, Semsi ; Knudsen, Nick ; Manibusan, Anthony ; Axup, Jun Y. ; Kim, Chan Hyuk ; Smider, Vaughn V. ; Javahishvili, Tsotne ; Schultz, Peter G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4606-e3994d00081448e54d2c867815cf83c97aa563898998d1319a56911d05499cc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>bispecific antibody</topic><topic>cancer</topic><topic>CD3 Complex - immunology</topic><topic>Cell Line, Tumor</topic><topic>Coculture Techniques</topic><topic>folate receptor</topic><topic>Folate Receptors, GPI-Anchored - metabolism</topic><topic>Folic Acid - chemistry</topic><topic>Humans</topic><topic>Immunoglobulin Fab Fragments - chemistry</topic><topic>Immunoglobulin Fab Fragments - immunology</topic><topic>Immunoglobulin Fc Fragments - chemistry</topic><topic>Immunoglobulin Fc Fragments - immunology</topic><topic>Immunoglobulin G - chemistry</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunotherapy</topic><topic>Leukocytes, Mononuclear - cytology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred NOD</topic><topic>Mice, SCID</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>T cells</topic><topic>T-Lymphocytes, Cytotoxic - cytology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kularatne, Sumith A.</creatorcontrib><creatorcontrib>Deshmukh, Vishal</creatorcontrib><creatorcontrib>Gymnopoulos, Marco</creatorcontrib><creatorcontrib>Biroc, Sandra L.</creatorcontrib><creatorcontrib>Xia, Jinming</creatorcontrib><creatorcontrib>Srinagesh, Shailaja</creatorcontrib><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Zou, Ning</creatorcontrib><creatorcontrib>Shimazu, Mark</creatorcontrib><creatorcontrib>Pinkstaff, Jason</creatorcontrib><creatorcontrib>Ensari, Semsi</creatorcontrib><creatorcontrib>Knudsen, Nick</creatorcontrib><creatorcontrib>Manibusan, Anthony</creatorcontrib><creatorcontrib>Axup, Jun Y.</creatorcontrib><creatorcontrib>Kim, Chan Hyuk</creatorcontrib><creatorcontrib>Smider, Vaughn V.</creatorcontrib><creatorcontrib>Javahishvili, Tsotne</creatorcontrib><creatorcontrib>Schultz, Peter G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kularatne, Sumith A.</au><au>Deshmukh, Vishal</au><au>Gymnopoulos, Marco</au><au>Biroc, Sandra L.</au><au>Xia, Jinming</au><au>Srinagesh, Shailaja</au><au>Sun, Ying</au><au>Zou, Ning</au><au>Shimazu, Mark</au><au>Pinkstaff, Jason</au><au>Ensari, Semsi</au><au>Knudsen, Nick</au><au>Manibusan, Anthony</au><au>Axup, Jun Y.</au><au>Kim, Chan Hyuk</au><au>Smider, Vaughn V.</au><au>Javahishvili, Tsotne</au><au>Schultz, Peter G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. 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| ispartof | Angewandte Chemie International Edition, 2013-11, Vol.52 (46), p.12101-12104 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| subjects | Animals bispecific antibody cancer CD3 Complex - immunology Cell Line, Tumor Coculture Techniques folate receptor Folate Receptors, GPI-Anchored - metabolism Folic Acid - chemistry Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology Immunoglobulin Fc Fragments - chemistry Immunoglobulin Fc Fragments - immunology Immunoglobulin G - chemistry Immunoglobulin G - immunology Immunotherapy Leukocytes, Mononuclear - cytology Male Mice Mice, Inbred NOD Mice, SCID Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Rats Rats, Sprague-Dawley T cells T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - immunology |
| title | Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells |
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