Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells

A Fab‐ulous killer: An anti‐CD3 Fab‐folate conjugate that targets cytotoxic T cells to folate‐receptor‐positive (FR+) tumors results in efficient killing of tumor cells by activated T cells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12101-12104
Hauptverfasser:	Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shailaja, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun Y., Kim, Chan Hyuk, Smider, Vaughn V., Javahishvili, Tsotne, Schultz, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bispecific antibody cancer CD3 Complex - immunology Cell Line, Tumor Coculture Techniques folate receptor Folate Receptors, GPI-Anchored - metabolism Folic Acid - chemistry Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology Immunoglobulin Fc Fragments - chemistry Immunoglobulin Fc Fragments - immunology Immunoglobulin G - chemistry Immunoglobulin G - immunology Immunotherapy Leukocytes, Mononuclear - cytology Male Mice Mice, Inbred NOD Mice, SCID Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Rats Rats, Sprague-Dawley T cells T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - immunology
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Beschreibung
Zusammenfassung:	A Fab‐ulous killer: An anti‐CD3 Fab‐folate conjugate that targets cytotoxic T cells to folate‐receptor‐positive (FR+) tumors results in efficient killing of tumor cells by activated T cells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal chemical reactivity affords homogenous conjugates with precise control over the relative geometry of the antibody binding sites in excellent yields.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201306866